Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis.

Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis. Research Abstract Details 

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Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis. Abstract Text:

Scott Valastyan,Varsha Thakur,Amy Johnson,Karan Kumar,Danny Manor,Scott Valastyan,Varsha Thakur,Amy Johnson,Karan Kumar,Danny Manor,

Vitamin E is a dietary lipid that is essential for vertebrate health and fertility. The biological activity of vitamin E is thought to reflect its ability to quench oxygen- and carbon-based free radicals and thus to protect the organism from oxidative damage. However, recent reports suggest that vitamin E may also display other biological activities. Here, to examine possible mechanisms that may underlie such nonclassical activities of vitamin E, we investigated the possibility that it functions as a specific modulator of gene expression. We show that treatment of cultured hepatocytes with (RRR)-alpha-tocopherol alters the expression of multiple genes and that these effects are distinct from those elicited by another antioxidant. Genes modulated by vitamin E include those that encode key enzymes in the cholesterol biosynthetic pathway. Correspondingly, vitamin E caused a pronounced inhibition of de novo cholesterol biosynthesis. The transcriptional activities of vitamin E were mediated by attenuating the post-translational processing of the transcription factor SREBP-2 that, in turn, led to a decreased transcriptional activity of sterol-responsive elements in the promoters of target genes. These observations indicate that vitamin E possesses novel transcriptional activities that affect fundamental biological processes. Cross talk between tocopherol levels and cholesterol status may be an important facet of the biological activities of vitamin E.

Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis. Publishing Authors By Initials

S Valastyan,V Thakur,A Johnson,K Kumar,D Manor,S Valastyan,V Thakur,A Johnson,K Kumar,D Manor,

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Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemistry

VOLUME: 47

Page Numbers: 744-52

Journal Abbreviation: Biochemistry

ISSN: 0006-2960

DAY: 21

MONTH: 12

YEAR: 2007

Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis. Information

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LANGUAGE: eng

NlmUniqueID: 370623

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Grant and Affiliation Information for Novel transcriptional activities of vitamin e: inhibition of cholesterol biosynthesis.

AFFILIATION: Cornell University, Ithaca, New York 14853, and Case Western Reserve University, Cleveland, Ohio 44106.

Country: United States

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MEDLINETA: Biochemistry

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