Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Research Abstract Details 

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Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Abstract Text:

John I Trujillo,Marvin J Meyers,David R Anderson,Shridhar Hegde,Matthew W Mahoney,William F Vernier,Ingrid P Buchler,Kun K Wu,Syaluan Yang,Susan J Hartmann,David B Reitz,

A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNFalpha production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity.

Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Publishing Authors By Initials

JI Trujillo,MJ Meyers,DR Anderson,S Hegde,MW Mahoney,WF Vernier,IP Buchler,KK Wu,S Yang,SJ Hartmann,DB Reitz,

For similar cells: cells, cultured: cell line: cell line, tumor: u937 cells research abstracts see: cells: cells, cultured: cell line: cell line, tumor: u937 cells research

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Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4657-63

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 25

MONTH: 05

YEAR: 2007

Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Keywords Mesh Terms:

KEYWORDS: U937 Cells

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

AFFILIATION: Department of Medicinal Chemistry, Pfizer Global Research and Development, Chesterfield, MO 63017, USA. john.i.trujillo@pfizer.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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