Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution.

Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Research Abstract Details 

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Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Abstract Text:

Beate Timmermann,Antony Jonathan Lomax,Luisa Nobile,Michael Andreas Grotzer,Markus Weiss,Rolf-Dieter Kortmann,Alessandra Bolsi,Gudrun Goitein,

BACKGROUND AND PURPOSE: Conventional craniospinal irradiation (CSI) is a complex procedure carrying a high risk of adverse side effects. Still, it is indispensable for cure in a number of pediatric brain tumors. In this study, the feasibility and the potential advantage of spot-scanning proton therapy for CSI are investigated. MATERIAL AND METHODS: A boy (5.5 years of age) with a recurrent medulloblastoma received CSI with a single posterior field using the spot-scanning system at Paul Scherrer Institute. Dose distribution to the targets and the organs at risk, treatment time, reproducibility of patient positioning, toxicity (according to EORTC/RTOG score), and treatment outcome were evaluated. RESULTS: The plan achieved a homogeneous coverage of the target volume, even using a single field. The doses to the organs ventral to the target were minimized. During treatment, grade 1 skin reaction and grade 2 central nervous system toxicity were observed. After 2 months, the boy presented with a transitory fatigue. After 24 months, he is alive and free of disease. Growth hormones and thyroid hormones are reduced. CONCLUSION: These results, based on a single patient, suggest that spot-scanning proton therapy for craniospinal treatment is feasible and safe. By applying a single dorsal field, difficulties of multiple-field patching can be avoided and the ventral dose spread can be minimized.

Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Publishing Authors By Initials

B Timmermann,AJ Lomax,L Nobile,MA Grotzer,M Weiss,RD Kortmann,A Bolsi,G Goitein,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Strahlentherapie und Onkologie : Organ der Deutsch

VOLUME: 183

Page Numbers: 685-8

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ISSN: 0179-7158

DAY: 11

MONTH: Dec

YEAR: 2007

Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Information

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LANGUAGE: eng

NlmUniqueID: 8603469

Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: instrumentation

Chemical & Substance for Abstract: Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Information

Substance Name: Protons

Registry Number: 0

Grant and Affiliation Information for Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution.

AFFILIATION: Center for Proton Radiation Therapy, Paul Scherrer Institute, Villigen, Switzerland. beate.timmermann@psi.ch

Country: Germany

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MEDLINETA: Strahlenther Onkol

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