Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure.

Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Research Abstract Details 

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Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Abstract Text:

Eiichiro Yamamoto,Keiichiro Kataoka,Haruo Shintaku,Takuro Yamashita,Yoshiko Tokutomi,Yi-Fei Dong,Shinji Matsuba,Hidenori Ichijo,Hisao Ogawa,Shokei Kim-Mitsuyama,Eiichiro Yamamoto,Keiichiro Kataoka,Haruo Shintaku,Takuro Yamashita,Yoshiko Tokutomi,Yi-Fei Dong,Shinji Matsuba,Hidenori Ichijo,Hisao Ogawa,Shokei Kim-Mitsuyama,

OBJECTIVE: The mechanism and role of angiotensin II-induced vascular endothelial injury is unclear. We examined the molecular mechanism of angiotensin (AII)-induced vascular endothelial injury and its significance for hypertensive diastolic heart failure. METHODS AND RESULTS: We compared the effect of valsartan and amlodipine on Dahl salt-sensitive hypertensive rats (DS rats). Valsartan improved vascular endothelial dysfunction of DS rats more than amlodipine, by inhibiting endothelial apoptosis and eNOS uncoupling more. Moreover, valsartan inhibited vascular apoptosis signal-regulating kinase 1 (ASK1) more than amlodipine. Thus, AT1 receptor contributed to vascular endothelial apoptosis, eNOS uncoupling, and ASK1 activation of DS rats. Using ASK1(-/-) mice, we examined the causative role of ASK1 in endothelial apoptosis and eNOS uncoupling. AII infusion in wild-type mice markedly caused vascular endothelial apoptosis and eNOS uncoupling accompanied by vascular endothelial dysfunction, whereas these effects of AII were absent in ASK1(-/-) mice. Therefore, ASK1 participated in AII-induced vascular endothelial apoptosis and eNOS uncoupling. Using tetrahydrobiopterin, we found that eNOS uncoupling was involved in vascular endothelial dysfunction in DS rats with established diastolic heart failure. CONCLUSIONS: AII-induced vascular endothelial apoptosis and eNOS uncoupling were mediated by ASK1 and contributed to vascular injury in diastolic heart failure of salt-sensitive hypertension.

Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Publishing Authors By Initials

E Yamamoto,K Kataoka,H Shintaku,T Yamashita,Y Tokutomi,YF Dong,S Matsuba,H Ichijo,H Ogawa,S Kim-Mitsuyama,E Yamamoto,K Kataoka,H Shintaku,T Yamashita,Y Tokutomi,YF Dong,S Matsuba,H Ichijo,H Ogawa,S Kim-Mitsuyama,

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Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Arteriosclerosis, thrombosis, and vascular biology

VOLUME: 27

Page Numbers: 2569-75

Journal Abbreviation: Arterioscler. Thromb. Vasc. Bi

ISSN: 1524-4636

DAY: 11

MONTH: 10

YEAR: 2007

Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Information

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LANGUAGE: eng

NlmUniqueID: 9505803

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AFFILIATION: Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjyo, Kumamoto 860-8556, Japan.

Country: United States

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MEDLINETA: Arterioscler Thromb Vasc Biol

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