Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-.

Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-. Research Abstract Details 

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Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-. Abstract Text:

Hui Yuan Gao,Li Jun Wu,Takahisa Nakane,Osamu Shirota,Masonori Kuroyanagi,

In the previous work we reported five A-seco-rearranged lanostane triterpenoids as antibacterial constituents from the ethyl acetate soluble fraction of Abies sachalinensei leaves. In further study on the isolation of constituents from the ethyl acetate soluble fraction, two new rearranged lanostane and lanostane-type triterpenoids (3, 4) and three reported compound (1, 2, 5) were isolated. The structures of new compound 3 and 4 were determined to be 3,4-seco-4(28),6,8(14),24-mariesatetraen-26,23-olide-23-hydroxy-3-oic acid and 3,4-seco-4(28),7,24-lanostatrien-26,23-olide-23-hydroxy-3-oic acid, respectively, by spectral studies on HR-MS, (1)H-NMR, (13)C-NMR, and 2D-NMR spectra. Compound 1 was identified with pindrolactone and its structure was revised as 7,14,22Z,24-mariesatetraen-26,23-olide-3alpha-ol. Structures of 2 and 5 were determined as 7,14,24-mariesatrien-26,23-olide-3alpha,23-diol and 3alpha-hydroxy-7,14,24E-mariesatrien-23-oxo-26-oic acid. Of these compounds, 2, 3 and 4 were obtained as lactol tautomer mixtures at gamma-lactone structures of side chains.

Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-. Publishing Authors By Initials

HY Gao,LJ Wu,T Nakane,O Shirota,M Kuroyanagi,

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Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical & pharmaceutical bulletin

VOLUME: 56

Page Numbers: 554-8

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 1

MONTH: Apr

YEAR: 2008

Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-.

AFFILIATION: School of Traditional Chinese Medicines, Shenyang Pharmaceutical University.

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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