Novel insights into lung transplant rejection by microarray analysis.

Novel insights into lung transplant rejection by microarray analysis. Research Abstract Details 

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Novel insights into lung transplant rejection by microarray analysis. Abstract Text:

Jeffrey D Lande,Jagadish Patil,Na Li,Todd R Berryman,Richard A King,Marshall I Hertz,

Gene expression microarrays can estimate the prevalence of mRNA for thousands of genes in a small sample of cells or tissue. Organ transplant researchers are increasingly using microarrays to identify specific patterns of gene expression that predict and characterize acute and chronic rejection, and to improve our understanding of the mechanisms underlying organ allograft dysfunction. We used microarrays to assess gene expression in bronchoalveolar lavage cell samples from lung transplant recipients with and without acute rejection on simultaneous lung biopsies. These studies showed increased expression during acute rejection of genes involved in inflammation, apoptosis, and T-cell activation and proliferation. We also studied gene expression during the evolution of airway obliteration in a murine heterotopic tracheal transplant model of chronic rejection. These studies demonstrated specific patterns of gene expression at defined time points after transplantation in allografts, whereas gene expression in isografts reverted back to that of native tracheas within 2 wk after transplantation. These studies demonstrate the potential power of microarrays to identify biomarkers of acute and chronic lung rejection. The application of new genetic, genomic, and proteomic technologies is in its infancy, and the microarray-based studies described here are clearly only the beginning of their application to lung transplantation. The massive amount of data generated per tissue or cell sample has spawned an outpouring of invention in the bioinformatics field, which is developing methodologies to turn data into meaningful and reproducible clinical and mechanistic inferences.

Novel insights into lung transplant rejection by microarray analysis. Publishing Authors By Initials

JD Lande,J Patil,N Li,TR Berryman,RA King,MI Hertz,

For similar surgical procedures, operative: transplantation: transplantation, heterotopic research abstracts see: surgical procedures, operative: transplantation: transplantation, heterotopic research

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Novel insights into lung transplant rejection by microarray analysis. Journal Published:

PUBLICATION TYPE: Review

Journal: Proceedings of the American Thoracic Society

VOLUME: 4

Page Numbers: 44-51

Journal Abbreviation:

ISSN: 1546-3222

DAY: 3

MONTH: Jan

YEAR: 2007

Novel insights into lung transplant rejection by microarray analysis. Information

Number of References: 77

LANGUAGE: eng

NlmUniqueID: 101203596

Novel insights into lung transplant rejection by microarray analysis. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterotopic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Novel insights into lung transplant rejection by microarray analysis. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Novel insights into lung transplant rejection by microarray analysis.

AFFILIATION: Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55405, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 5T32HL07741

ACRONYM: HL

MEDLINETA: Proc Am Thorac Soc

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