Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates.

Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Research Abstract Details 

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Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Abstract Text:

Nikhil J Kavimandan,Elena Losi,Nicholas A Peppas,

A variety of approaches have been investigated to address the problems associated with oral insulin delivery, but the bioavailability of oral insulin is still low. Insulin is rapidly degraded by the enzymes in the GI tract and is not transported across the epithelial barrier easily. The oral insulin formulation developed in this work makes use of complexation hydrogels for oral delivery of insulin bioconjugates. The insulin bioconjugates synthesized in this work consist of insulin bound to transferrin molecule which can be uptaken by the epithelial cells. The conjugates can increase the permeability of insulin across the epithelial barrier by receptor-mediated transcytosis. The transferrin in the conjugate is also shown to stabilize insulin in the presence of intestinal enzymes. Use of complexation hydrogels for delivery of insulin-transferrin conjugate may greatly increase the bioavailability of oral insulin. This is because, the complexation hydrogels are known to exhibit characteristics that make them ideal candidates for oral protein delivery. They can also inhibit the degradation of insulin in the GI tract. Thus, combination of these two approaches may provide an innovative platform for oral insulin delivery.

Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Publishing Authors By Initials

NJ Kavimandan,E Losi,NA Peppas,

For similar proteins: blood proteins: acute-phase proteins: transferrin research abstracts see: proteins: blood proteins: acute-phase proteins: transferrin research

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Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomaterials

VOLUME: 27

Page Numbers: 3846-54

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 10

MONTH: 03

YEAR: 2006

Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Information

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LANGUAGE: eng

NlmUniqueID: 8100316

Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Keywords Mesh Terms:

KEYWORDS: Transferrin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Information

Substance Name: polymethacrylic acid

Registry Number: 25087-26-7

Grant and Affiliation Information for Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates.

AFFILIATION: Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Country: England

AGENCY: United States NIBIB

GRANT: R01 EB000246

ACRONYM: EB

MEDLINETA: Biomaterials

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