Novel Approaches to Imatinib- and Sunitinib-Resistant GIST.

Novel Approaches to Imatinib- and Sunitinib-Resistant GIST. Research Abstract Details 

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Novel Approaches to Imatinib- and Sunitinib-Resistant GIST. Abstract Text:

Gastrointestinal stromal tumors (GISTs) generally arise from primary activating mutations in the KIT or PDGFRA genes that result in constitutive activation of receptor tyrosine kinase activity. Imatinib provides targeted therapy for GIST by inhibiting the KIT and PDGFR-alpha tyrosine kinases. Clinical benefit is achieved in approximately 85% of patients with unresectable or metastatic disease, with a median progression-free survival of 20 to 24 months. The mechanisms of acquired resistance to imatinib are heterogeneous, with most involving the emergence of secondary mutations in KIT exons 13, 14, or 17. In patients failing or intolerant to imatinib, the multitargeted agent sunitinib achieves durable disease control in approximately 50% of cases. Experimental treatment options beyond those currently available consist of other KIT-targeting tyrosine kinase inhibitors, such as nilotinib, or agents targeting alternative pathways, such as antiangiogenic agents, mammalian target of rapamycin, RAF kinase, and chaperone inhibitors.

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Novel Approaches to Imatinib- and Sunitinib-Resistant GIST. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current oncology reports

VOLUME: 10

Page Numbers: 344-9

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ISSN: 1534-6269

DAY: 9

MONTH: Jul

YEAR: 2008

Novel Approaches to Imatinib- and Sunitinib-Resistant GIST. Information

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LANGUAGE: eng

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AFFILIATION: Helios Klinikum Bad Saarow, Department of Hematology, Oncology, and Palliative Care, Sarcoma Center Berlin-Brandenburg, Pieskower Strasse 33, 15526 Bad Saarow, Germany. peter.reichardt@helios-kliniken.de.

Country: United States

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MEDLINETA: Curr Oncol Rep

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