Notch signaling regulates midline cell specification and proliferation in zebrafish.

Notch signaling regulates midline cell specification and proliferation in zebrafish. Research Abstract Details 

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Notch signaling regulates midline cell specification and proliferation in zebrafish. Abstract Text:

Andrew J Latimer,Bruce Appel,

Notochord and floor plate cells are sources of molecules that pattern tissues near the midline, including the spinal cord. Hypochord cells are also found at the midline of anamniote embryos and are important for aorta development. Delta-Notch signaling regulates midline patterning in the dorsal organizer by inhibiting notochord formation and promoting hypochord and possibly floor plate development, but the precise mechanisms by which this regulation occurs are unknown. We demonstrate here that floor plate and hypochord cells arise from distinct regions of the zebrafish shield. Blocking Notch signaling during gastrulation entirely prevented hypochord specification but only reduced the number of floor plate cells that developed compared to control embryos. In contrast, elevation of Notch signaling at the beginning of gastrulation caused expansion of hypochord at the expense of notochord, but floor plate was not affected. A cell proliferation assay revealed that Notch signaling maintains dividing floor plate progenitors. Together, our results indicate that Notch signaling regulates allocation of appropriate numbers of different midline cells by different mechanisms.

Notch signaling regulates midline cell specification and proliferation in zebrafish. Publishing Authors By Initials

AJ Latimer,B Appel,

For similar proteins: fish proteins: zebrafish proteins research abstracts see: proteins: fish proteins: zebrafish proteins research

PUBMED ID PMID:

MEDLINE DATE:

Notch signaling regulates midline cell specification and proliferation in zebrafish. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental biology

VOLUME: 298

Page Numbers: 392-402

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 30

MONTH: 06

YEAR: 2006

Notch signaling regulates midline cell specification and proliferation in zebrafish. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

Notch signaling regulates midline cell specification and proliferation in zebrafish. Keywords Mesh Terms:

KEYWORDS: Zebrafish Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Notch signaling regulates midline cell specification and proliferation in zebrafish. Information

Substance Name: ntl protein, zebrafish

Registry Number: 0

Grant and Affiliation Information for Notch signaling regulates midline cell specification and proliferation in zebrafish.

AFFILIATION: Department of Biological Sciences, Vanderbilt University, U7211 BSB/MRBIII, 465 21st Avenue South, Nashville, TN 37232, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD 38118

ACRONYM: HD

MEDLINETA: Dev Biol

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Number Hits: 0

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