Notch signaling in osteoblasts.

Notch signaling in osteoblasts. Research Abstract Details 

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Notch signaling in osteoblasts. Abstract Text:

Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.

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PUBLICATION TYPE: Journal Article

Journal: Science signaling

VOLUME: 1

Page Numbers: pe17

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ISSN: 1937-9145

DAY: 29

MONTH: 04

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101465400

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Grant and Affiliation Information for Notch signaling in osteoblasts.

AFFILIATION: Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA, and University of Connecticut School of Medicine, Farmington, CT 06030, USA.

Country: United States

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MEDLINETA: Sci Signal

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