NOTCH and PI3K-AKT pathways intertwined.

NOTCH and PI3K-AKT pathways intertwined. Research Abstract Details 

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NOTCH and PI3K-AKT pathways intertwined. Abstract Text:

Alejandro Gutierrez,A Thomas Look,Alejandro Gutierrez,A Thomas Look,

Constitutive signaling by the NOTCH1 receptor contributes to more than half of all cases of T cell acute lymphoblastic leukemia (T-ALL). However, blocking the proteolytic activation of NOTCH1 with gamma-secretase inhibitors (GSIs) fails to alter the growth of some T-ALL cell lines carrying the mutated receptor. A recent report by Palomero et al. in Nature Medicine identifies loss of PTEN as a critical event leading to resistance to NOTCH inhibition, which causes the transfer of "oncogene addiction" from the NOTCH1 to the PI3K/AKT pathway. This novel observation suggests the need to simultaneously inhibit both pathways as a means to improve therapeutic efficacy in human T-ALL.

NOTCH and PI3K-AKT pathways intertwined. Publishing Authors By Initials

A Gutierrez,AT Look,A Gutierrez,AT Look,

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NOTCH and PI3K-AKT pathways intertwined. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer cell

VOLUME: 12

Page Numbers: 411-3

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ISSN: 1535-6108

DAY: 12

MONTH: Nov

YEAR: 2007

NOTCH and PI3K-AKT pathways intertwined. Information

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LANGUAGE: eng

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Grant and Affiliation Information for NOTCH and PI3K-AKT pathways intertwined.

AFFILIATION: Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Country: United States

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MEDLINETA: Cancer Cell

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