Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication.

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Research Abstract Details 

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Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Abstract Text:

Chungwon Chung,Wonhee Lee,John T Loffredo,Benjamin Burwitz,Thomas C Friedrich,Juan Pablo Giraldo Vela,Gnankang Napoe,Eva G Rakasz,Nancy A Wilson,David B Allison,David I Watkins,

Current assays of CD8+ T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8+ T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef(165-173)IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2.

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Publishing Authors By Initials

C Chung,W Lee,JT Loffredo,B Burwitz,TC Friedrich,JP Giraldo Vela,G Napoe,EG Rakasz,NA Wilson,DB Allison,DI Watkins,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 1517-23

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 29

MONTH: 11

YEAR: 2006

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: physiology

Chemical & Substance for Abstract: Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Information

Substance Name: Cytokines

Registry Number: 0

Grant and Affiliation Information for Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication.

AFFILIATION: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715-1299, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR15459-01

ACRONYM: RR

MEDLINETA: J Virol

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