Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis.

Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Research Abstract Details 

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Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Abstract Text:

Lh Lu,Cm Leonard,Pm Thompson,E Kan,J Jolley,Se Welcome,Aw Toga,Er Sowell,

This study asked whether previously identified developmental changes in the gray matter of the left inferior frontal gyrus are associated with maturation of a linguistic skill. To test this hypothesis, we examined whether thickening of this region was correlated with developmental improvements in phonological processing but not hand motor skills in a unique longitudinal data set of 45 normally developing children (between ages 5 and 11 years) studied over a 2-year interval. We analyzed structural magnetic resonance imaging data using cortical pattern matching methods and correlated within-individual changes in cortical thickness with 2 neurocognitive scores. As predicted, gray matter thickening in the left inferior frontal cortex was associated with improving phonological processing scores but not with improving hand motor skills. By contrast, motor skill improvement was associated with thinning in the hand region of the left motor cortex, and cortical change in this region was not associated with phonological processing. This study illustrates a specific correspondence between regional gray matter thickness change and language skill change in normally developing children.

Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Publishing Authors By Initials

L Lu,C Leonard,P Thompson,E Kan,J Jolley,S Welcome,A Toga,E Sowell,

For similar psychological phenomena and processes: mental processes: perception: auditory perception: speech perception research abstracts see: psychological phenomena and processes: mental processes: perception: auditory perception: speech perception research

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Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cerebral cortex (New York, N.Y. : 1991)

VOLUME: 17

Page Numbers: 1092-9

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ISSN: 1047-3211

DAY: 16

MONTH: 06

YEAR: 2006

Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Information

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LANGUAGE: eng

NlmUniqueID: 9110718

Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Keywords Mesh Terms:

KEYWORDS: Speech Perception

MESH TERMS: physiology

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Grant and Affiliation Information for Normal developmental changes in inferior frontal gray matter are associated with improvement in phonological processing: a longitudinal MRI analysis.

AFFILIATION: Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095-1769, USA. lisa.lu@loni.ucla.edu

Country: United States

AGENCY: United States NCRR

GRANT: U54 RR021813

ACRONYM: RR

MEDLINETA: Cereb Cortex

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