Normal and Pathological Aging of Attention in Presymptomatic Huntington's, Huntington's and Alzheimer's Disease, and Nondemented Elderly Subjects.

Normal and Pathological Aging of Attention in Presymptomatic Huntington's, Huntington's and Alzheimer's Disease, and Nondemented Elderly Subjects. Research Abstract Details 

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Normal and Pathological Aging of Attention in Presymptomatic Huntington's, Huntington's and Alzheimer's Disease, and Nondemented Elderly Subjects. Abstract Text:

Charles-Siegfried Peretti,Florian Ferreri, Blanchard,Serge Bakchine,Charles Roger Peretti,Andrei Dobrescu,Virginie-Anne Chouinard,Guy Chouinard,Charles-Siegfried Peretti,Florian Ferreri, Blanchard,Serge Bakchine,Charles Roger Peretti,Andrei Dobrescu,Virginie-Anne Chouinard,Guy Chouinard,

Background: Attention models view attention as having at least two components: endogenous attention defined as executive and directed by voluntary acts, and exogenous attention defined as automatic and directed by external stimulation. Methods: Three studies (2 of our own) were designed to evaluate the decline of these two components of attention in normal aging and two neurodegenerative diseases. Standardized tests derived from Posner's model of visuospatial attention were administered to normal healthy elderly participants (n = 13), patients suffering from Huntington's disease (HD; n = 17) and Alzheimer's disease (n = 15), and matched control subjects (n = 57). Outcome measures were reaction time (RT) and RT difference score (defined as invalid RT minus valid RT). Results: In healthy elderly participants, the decline was more pronounced for endogenous attention in situations of perceptual conflict. In Alzheimer's disease, there was a significant decline in both attention components, while in HD, voluntary attention was markedly impaired and automatic attention preserved. Conclusions: Normal aging and HD are characterized by decreased endogenous attention in situations of perceptual conflict. Our data support previous findings that older people display impairment of attention in complex perceptual situations. We propose a model which allows for the separation of attention pathologies, thus improving therapeutic strategies for patients and elderly. Copyright (c) 2008 S. Karger AG, Basel.

Normal and Pathological Aging of Attention in Presymptomatic Huntington's, Huntington's and Alzheimer's Disease, and Nondemented Elderly Subjects. Publishing Authors By Initials

CS Peretti,F Ferreri,F Blanchard,S Bakchine,CR Peretti,A Dobrescu,VA Chouinard,G Chouinard,CS Peretti,F Ferreri,F Blanchard,S Bakchine,CR Peretti,A Dobrescu,VA Chouinard,G Chouinard,

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Normal and Pathological Aging of Attention in Presymptomatic Huntington's, Huntington's and Alzheimer's Disease, and Nondemented Elderly Subjects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychotherapy and psychosomatics

VOLUME: 77

Page Numbers: 139-46

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ISSN: 1423-0348

DAY: 14

MONTH: 02

YEAR: 2008

Normal and Pathological Aging of Attention in Presymptomatic Huntington's, Huntington's and Alzheimer's Disease, and Nondemented Elderly Subjects. Information

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LANGUAGE: eng

NlmUniqueID: 24046

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AFFILIATION: Service de psychiatrie et de psychologie médicale, Hôpital Saint-Antoine, Université Pierre et Marie Curie, Paris, France.

Country: Switzerland

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MEDLINETA: Psychother Psychosom

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