Norepinephrine transporter gene variation modulates acute response to D-amphetamine.

Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Research Abstract Details 

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Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Abstract Text:

Andrea Dlugos,Christine Freitag,Christa Hohoff,Jennifer McDonald,Edwin H Cook, Deckert,Harriet de Wit,

BACKGROUND: Individual differences in subjective responses to stimulant drugs such as amphetamine may influence risk of abuse as well as clinical-treatment response to these drugs. Because the effects of amphetamine are mediated in part by the norepinephrine transporter (SLC6A2), we examined interindividual differences in mood response to amphetamine in relation to SLC6A2 gene polymorphisms. METHODS: Ninety-nine healthy volunteers participated in three sessions in which they randomly received either placebo or D-amphetamine (10 mg or 20 mg) under double-blind conditions. Every subject completed self-report measures on subjective effects (Profile of Mood States). Afterward, all individuals were genotyped for eight SLC6A2 gene polymorphisms. Individual genotypes and haplotypes were investigated. RESULTS: The intronic 36001C/C (rs47958) genotype was associated with increases in positive mood and elation after 20 mg of D-amphetamine. Positive mood and elation levels were also found to be associated with the haplotype GCC formed from 28257G/C (rs36017), 28323C/T (rs2270935), and 36001A/C (rs47958). These findings remained significant after adjustment for multiple testing. CONCLUSIONS: Polymorphisms in the SLC6A2 gene were associated with mood responses to D-amphetamine. If confirmed, this observation may contribute to a better understanding of interindividual variations in the clinical response to amphetamine and in the risk of becoming addicted to amphetamine.

Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Publishing Authors By Initials

A Dlugos,C Freitag,C Hohoff,J McDonald,EH Cook,J Deckert,H de Wit,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 1296-305

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 17

MONTH: 01

YEAR: 2007

Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Norepinephrine transporter gene variation modulates acute response to D-amphetamine.

AFFILIATION: Department of Psychiatry, University of Münster, Münster, Germany.

Country: United States

AGENCY: United States NCRR

GRANT: M01RR00055

ACRONYM: RR

MEDLINETA: Biol Psychiatry

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