[Nontargeted effects of ionizing radiation: implications for low-dose exposures]

[Nontargeted effects of ionizing radiation: implications for low-dose exposures] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Nontargeted effects of ionizing radiation: implications for low-dose exposures] Abstract Text:

J B Little,

The traditional thinking has been that the biological effects of ionizing radiation occur in irradiated cells as a consequence of the DNA damage they incur. This implies that: 1) biological effects occur only in irratiated cells, 2) radiation traversal through the nucleus of the cell is a prerequisite to produce a biological response, and 3) DNA is the target molecule in the cell. Evidence has been emerging, however, for non-DNA targeted effects of radiation; that is, effects including mutations, chromosomal aberrations, and changes in gene expression which occur in cells that in themselves receive no radiation exposure. Two of these phenomena will be described in this paper. The first is radiation-induced genomic instability whereby biological effects, including elevated frequencies of mutations and chromosomal aberrations, arise in the distant descendants of irradiated cells. The second phenomenon has been termed the "bystander effect", whereby in a mixed population of irradiated and nonirradiated cells, biological effects arise in those cells that receive no radiation exposure. The damage signals are transmitted from cell to cell through gap junction channels, and the genetic effects observed in bystander cells appear to result from an upregulation of oxidative stress. The possible influence of these non-targeted effects of radiation of the respounse to low-dose exposures is discussed.

[Nontargeted effects of ionizing radiation: implications for low-dose exposures] Publishing Authors By Initials

JB Little,

For similar natural sciences: physics: radiation: radiation, ionizing research abstracts see: natural sciences: physics: radiation: radiation, ionizing research

PUBMED ID PMID:

MEDLINE DATE: 2007 May-Jun

[Nontargeted effects of ionizing radiation: implications for low-dose exposures] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Radiatsionnaia biologiia, radioecologiia / Rossi?s

VOLUME: 47

Page Numbers: 262-72

Journal Abbreviation:

ISSN: 0869-8031

DAY: 3

MONTH: 12

YEAR: 2007

[Nontargeted effects of ionizing radiation: implications for low-dose exposures] Information

Number of References:

LANGUAGE: rus

NlmUniqueID: 9317212

[Nontargeted effects of ionizing radiation: implications for low-dose exposures] Keywords Mesh Terms:

KEYWORDS: Radiation, Ionizing

MESH TERMS: radiation effects

Chemical & Substance for Abstract: [Nontargeted effects of ionizing radiation: implications for low-dose exposures] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Nontargeted effects of ionizing radiation: implications for low-dose exposures]

AFFILIATION:

Country: Russia (Federation)

AGENCY: United States NCI

GRANT: CA-47542

ACRONYM: CA

MEDLINETA: Radiats Biol Radioecol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Nontargeted effects of ionizing radiation: implications for low-dose exposures Related Publications

• 690.
• 9 Multicellular Sprouting during Vasculogenesis.
• A synthetic phage lambda regulatory circuit.
• Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
• Circulating antidiuretic hormone in the X-irradiated rat.
• Clinical utility of HIV standard genotyping among antiretroviral-naive individuals with unknown duration of infection.
• Congenital anomalies of the male urethra.
• Conjunctival sweeping with a squint hook to reduce chemosis.
• Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant.
• Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.
• Definition and spatial annotation of the dynamic secretome during early kidney development.
• Evidence for adaptive design in human gaze preference.
• Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR.
• Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease.
• Grandparents raising grandchildren:kinship care in Baltimore public housing.
• Guest Editorial: Electronic aids for daily living.
• Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection.
• Humidified air inhalation for treating croup: a systematic review and meta-analysis.
• Justifying knowledge, justifying method, taking action: epistemologies, methodologies, and methods in qualitative research.
• Lauriston S. Taylor lecture: nontargeted effects of radiation: implications for low-dose exposures.
• Long-term persistence of transmitted HIV drug resistance in male genital tract secretions: implications for secondary transmission.
• Posterior sloping angle of the capital femoral physis: interobserver and intraobserver reliability testing and predictor of bilaterality.
• Relative quantitation of virus population size in mixed genotype infections using sequencing chromatograms.
• Risk and benefit: the eternal Yin and Yang of thoracic surgery.
• Risky Sexual Behavior and Management of Sexually Transmitted Diseases: 163: 8:55 AM-9:20 AM.
• Sexual communication and contraceptive use in adolescent dating couples.
• Structural aging: the facial recurve concept.
• The deformity index as a predictor of final radiological outcome in Perthes' disease.
• White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study.
• [Nontargeted effects of ionizing radiation: implications for low-dose exposures]