Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Abstract Text:

The majority of regulatory Foxp3+CD4+ T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery.

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Publishing Authors By Initials

For similar nutritional and metabolic diseases: metabolic diseases: wasting syndrome research abstracts see: nutritional and metabolic diseases: metabolic diseases: wasting syndrome research

PUBMED ID PMID:

MEDLINE DATE:

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunity

VOLUME: 27

Page Numbers: 493-504

Journal Abbreviation: Immunity

ISSN: 1074-7613

DAY: 3

MONTH: Sep

YEAR: 2007

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432918

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Keywords Mesh Terms:

KEYWORDS: Wasting Syndrome

MESH TERMS: immunology

Chemical & Substance for Abstract: Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Information

Substance Name: Receptors, Antigen, T-Cell

Registry Number: 0

Grant and Affiliation Information for Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.

AFFILIATION: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA. rpacholczyk@mcg.edu

Country: United States

AGENCY: United States NCI

GRANT: CA107349-01A1

ACRONYM: CA

MEDLINETA: Immunity

REFSOURCE: Immunity. 2007 Sep;27(3):417-9

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells Related Publications

• Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.
• [Diagnostic and prognostic problems in early-childhood epilepsy with particular reference to West syndrome]
• [Haemobilia in the course of acenocoumarol overdosage in patient with cholelithiasis--case report]
• [TREATMENT OF NOCTURNAL ENURESIS WITH LASKOV'S APPARATUS.]