Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats.

Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Research Abstract Details 

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Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Abstract Text:

Angiotensin II (AII) appears essential in remnant kidney models of renal injury in rats, and renal injury was reduced by angiotensin-converting enzyme inhibitor (ACEI). To determine whether this is due to AII blockade or other actions of ACEI, we studied a nonpeptide AII type 1 receptor antagonist and an ACEI in partially nephrectomised spontaneously hypertensive rats (SHR). Thirty SHR underwent surgery and were divided into three equal groups: Control, TCV (0.5 mg/kg/day TCV-116), and CAP (30 mg/kg/day captopril). All SHR received a 5%-NaCl diet. Systolic blood pressure (SBP) and urinary protein were measured at 2-week intervals. Serum total protein, albumin, urea nitrogen, and creatinine were determined at week 8. Glomerular filtration rate (GFR) and renal blood flow (RBF) were measured at weeks 4 and 8. Renal injury was evaluated histopathologically. TCV and CAP reduced SBP at week 2 and proteinuria at week 8. GFR and RBF fell in all groups, but decreases were not significant in treated SHR and histopathological changes were significantly ameliorated. All blockade by TCV or CAP reduces renal injury in salt-loaded SHR with partial renal ablation. AII is essential in remnant kidney models of renal injury, and AII blockade is essential in renal protection by ACEI.

Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Publishing Authors By Initials

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: tetrazoles research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: tetrazoles research

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Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood pressure. Supplement

VOLUME: 5

Page Numbers: 67-70

Journal Abbreviation:

ISSN: 0803-8023

DAY: 26

MONTH: 02

YEAR: 1994

Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Information

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LANGUAGE: eng

NlmUniqueID: 9300787

Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Keywords Mesh Terms:

KEYWORDS: Tetrazoles

MESH TERMS: drug effects

Chemical & Substance for Abstract: Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats. Information

Substance Name: Captopril

Registry Number: 62571-86-2

Grant and Affiliation Information for Nonpeptide angiotensin II type 1 receptor antagonist prevents nephrosclerosis in hypertensive rats.

AFFILIATION: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Country: NORWAY

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MEDLINETA: Blood Press Suppl

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