Noninvasive imaging of receptor function: Signal transduction pathways and physiological readouts.

Noninvasive imaging of receptor function: Signal transduction pathways and physiological readouts. Research Abstract Details 

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Noninvasive imaging of receptor function: Signal transduction pathways and physiological readouts. Abstract Text:

Intracellular signaling describes the process of information propagation from the cell surface to the location within the cell where a biological response is executed. Signaling pathways involve a complex network of interacting molecular species. It is obvious that information on the activation of individual pathways is highly relevant in biomedical research, both from a diagnostic point of view and for evaluating therapeutic interventions. Modern molecular imaging approaches are capable of providing such information in a temporo-spatially resolved manner. Two strategies can be pursued: imaging individual pathway molecules or targeting protein-protein interactions, which are key elements of the signaling networks. Assays such as fluorescence resonance energy transfer, two-hybrid, protein fragment complementation or protein splicing have been adapted to allow studies in live mice. The major issues in imaging signal transduction are sensitivity, as critical species occur at low concentration, and the fact that the processes targeted are intracellular, that is, exogenous probes have to cross the cell membrane. Currently, the majority of these imaging methods are based on genetic engineering approaches and are therefore confined to experimental studies in animals. Exogenous probes for targeting intracellular pathway molecules are being developed and may allow translation into the clinic.

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Noninvasive imaging of receptor function: Signal transduction pathways and physiological readouts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in drug discovery & development

VOLUME: 11

Page Numbers: 606-15

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ISSN: 1367-6733

DAY: 27

MONTH: Sep

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Noninvasive imaging of receptor function: Signal transduction pathways and physiological readouts.

AFFILIATION: Institute for Biomedical Engineering, UZH/ETH Zürich and Institute for Pharmacology and Toxicology, University of Zürich, HCI-D426, CH-8093 Zürich, Switzerland. rudin@biomed.ee.ethz.ch.

Country: England

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MEDLINETA: Curr Opin Drug Discov Devel

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