Noncomparative contraceptive efficacy of cellulose sulfate gel.

Noncomparative contraceptive efficacy of cellulose sulfate gel. Research Abstract Details 

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Noncomparative contraceptive efficacy of cellulose sulfate gel. Abstract Text:

Christine K Mauck,Ron G Freziers,Terri L Walsh,Karen Peacock,Jill L Schwartz,Marianne M Callahan,

OBJECTIVE: To estimate the 6-month cumulative probability of pregnancy, short-term adverse effects, and acceptability of cellulose sulfate vaginal contraceptive gel. METHODS: Two hundred fertile heterosexual couples were enrolled in this single-center, phase II, 6-month noncomparative study conducted at the California Family Health Council in Los Angeles, California. Couples did not desire pregnancy, were at low risk for sexually transmitted diseases, and agreed to use 3.5 mL of cellulose sulfate gel intravaginally before each coital act as their primary means of contraception. Scheduled follow-up visits took place after one menstrual cycle and at study completion, which occurred after 6 months and six menstrual cycles had elapsed. In addition, participants were instructed to call the site at the onset of each menses to review their diary cards. RESULTS: The cumulative probabilities of pregnancy during 6 months and six cycles of typical use were 13.4% (95% confidence interval [CI] 7.5-19.4%) and 13.9% (95% CI 7.7-20.2%), respectively, and during 6 cycles of correct and consistent ("perfect") use: 3.9% (95% CI 0.0-9.2%). Slightly over one fourth of the women and one man reported experiencing gel-related adverse events, two thirds of which were mild and only possibly related to the gel. Three quarters of women and men reported that they would buy cellulose sulfate gel for contraception. CONCLUSION: Cellulose sulfate vaginal gel yields pregnancy rates comparable to nonoxynol-9 and few adverse events among couples at low risk for sexually transmitted diseases. LEVEL OF EVIDENCE: II.

Noncomparative contraceptive efficacy of cellulose sulfate gel. Publishing Authors By Initials

CK Mauck,RG Freziers,TL Walsh,K Peacock,JL Schwartz,MM Callahan,

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Noncomparative contraceptive efficacy of cellulose sulfate gel. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Obstetrics and gynecology

VOLUME: 111

Page Numbers: 739-46

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ISSN: 0029-7844

DAY: 3

MONTH: Mar

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Noncomparative contraceptive efficacy of cellulose sulfate gel.

AFFILIATION: CONRAD, Eastern Virginia Medical School (EVMS), Arlington, Virginia; and California Family Health Council, Los Angeles, California.

Country: United States

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MEDLINETA: Obstet Gynecol

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