Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase.

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Abstract Text:

Floria Pancetti,Cristina Olmos,Alexies Dagnino-Subiabre,Carlos Rozas,Bernardo Morales,Floria Pancetti,Cristina Olmos,Alexies Dagnino-Subiabre,Carlos Rozas,Bernardo Morales,

Organophosphate pesticides have been classically described as inhibitors of acetylcholinesterase (AChE) activity in insects and invertebrates. However, there is now more evidence supporting the hypothesis that these compounds also act through noncholinergic pathways, especially those related to cognitive processes. The enzyme acylpeptide hydrolase was identified as a new target for organophosphate pesticides. This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer's disease. Therefore, there is some doubt as to whether the mechanism of action of this drug is mediated by a potentiation of cholinergic transmission. However, the direct action of acylpeptide hydrolase in cognitive processes and the physiological and molecular mechanisms underlying subacute exposure to OP have yet to be demonstrated. This review deals with evidence demonstrating the existence of mechanisms of actions of OP, which are independent of cholinergic pathway potentiation and which have an effect on cognitive processes. In addition, the possible participation of the enzyme acylpeptide hydrolase in these processes is also discussed. Finally, the possibility of using this enzyme activity as a new biomarker for exposure to OP is considered.

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Publishing Authors By Initials

F Pancetti,C Olmos,A Dagnino-Subiabre,C Rozas,B Morales,F Pancetti,C Olmos,A Dagnino-Subiabre,C Rozas,B Morales,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of toxicology and environmental health. Pa

VOLUME: 10

Page Numbers: 623-30

Journal Abbreviation:

ISSN: 1521-6950

DAY: 30

MONTH: Dec

YEAR: 2007

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802627

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase.

AFFILIATION: Laboratory of Environmental Neurotoxicology, Department of Biological Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile. pancetti@ucn.cl

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Toxicol Environ Health B Cri

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase Related Publications

• An attempt to detect phosphorylated myosin by ADP-ATP exchange.
• C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure.
• Chondrocyte moves: clever strategies?
• DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.
• Defining the role of insulin detemir in Basal insulin therapy.
• Development of an ultra-performance liquid chromatography technique coupled with mass spectrometry for the measurement of tacrolimus in micro-samples of whole blood, and its application on a pharmacokiinetic trial.
• Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function?
• Effect of in vitro enzymatic digestion on antioxidant activity of coffee melanoidins and fractions.
• Fluorescence staining of glycerinated myofibrils with 1-anilino naphthalene-8-sulfonate.
• Frequency and causes of infectious abortion in a dairy herd in Queretaro, Mexico.
• GABAergic processes in the mesencephalic tegmentum modulate the occurrence of active (rapid eye movement) sleep in guinea pigs.
• Influence of the new immunosuppressive combinations on arterial hypertension after renal transplantation.
• Iron-deficiency anemia as presentation of pouchitis.
• Language access services for Latinos with limited English proficiency: lessons learned from Hablamos Juntos.
• Life-history strategies of plant pathogens: distribution patterns and phylogenetic analysis.
• Nanopore current transduction analysis of protein binding to non-terminal and terminal DNA regions: analysis of transcription factor binding, retroviral DNA terminus dynamics, and retroviral integrase-DNA binding.
• Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase.
• P31.15: First results of biochemical screening and combined ultrasound of fetal chromosomal disorders in the first trimester of pregnancy in Ecuador.
• Patterns of early adherence to the antidepressant citalopram among older primary care patients: the prospect study.
• Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
• Relations and effects of transformational leadership: a comparative analysis with traditional leadership styles.
• Relationship Between Body Mass Index and Measures of Sport Participation in Junior Female Volleyball Players: 2143: Board #56 June 1 9:00 AM - 10:30 AM.
• Renal damage associated with proteinuria.
• Responding to human trafficking in Connecticut: a guide for health-care providers.
• Structural control over well productivity in the Jundiaí River Catchment, Southeastern Brazil.
• Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic.
• Unmasking the Brugada syndrome with high parasternal leads.
• Words of wisdom. Re: detection of circulating urothelial cancer cells in the blood using the CellSearch system.
• Xenopus laevis: a possible vector of ranavirus infection?
• [Introduction: clinical relevance of graft-induced immunological injury after renal transplantation]