Nonalcoholic Fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets.

Nonalcoholic Fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Research Abstract Details 

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Nonalcoholic Fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Abstract Text:

Jacob George,Christopher Liddle,

Nonalcoholic fatty liver disease (NAFLD) is a consequence of insulin resistance encompassing a spectrum that extends from simple hepatic steatosis through to nonalcoholic steatohepatitis (NASH), a condition that may progress to cirrhosis with its associated complications. A subset of nuclear receptors act as intracellular sensors for cholesterol metabolites, free fatty acids, and a range of other lipophilic molecules with pivotal roles in energy homeostasis and inflammation. These receptors represent attractive drug targets for the management of NAFLD and NASH as well as related conditions such as type 2 diabetes and the broader metabolic syndrome. To date, human studies have concentrated on peroxisome proliferator-activated receptor (PPAR) agonists, particularly those directed at PPARgamma. However, these drugs have significant limitations, so alternate approaches to nuclear receptor targeting are being explored.

Nonalcoholic Fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Publishing Authors By Initials

J George,C Liddle,

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MEDLINE DATE: 2008 Jan-Feb

Nonalcoholic Fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular pharmaceutics

VOLUME: 5

Page Numbers: 49-59

Journal Abbreviation: Mol. Pharm.

ISSN: 1543-8384

DAY: 12

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: c.liddle@usyd.edu.au.

Country: United States

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MEDLINETA: Mol Pharm

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