Nonadherence to antiretroviral therapy among a community with endemic rates of injection drug use.

Nonadherence to antiretroviral therapy among a community with endemic rates of injection drug use. Research Abstract Details 

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Nonadherence to antiretroviral therapy among a community with endemic rates of injection drug use. Abstract Text:

Kate Shannon,Thomas Kerr,Calvin Lai,Tomiye Ishida,Evan Wood,Julio S G Montaner,Robert S Hogg,Mark W Tyndall,

Highly active antiretroviral therapy (HAART) has resulted in major reductions in HIV-related morbidity and mortality. However, long-term use of HAART is challenging, and substantial numbers of patients discontinue their medications prematurely. The purpose of this analysis is to describe HAART adherence rates among a large urban cohort and examine factors associated with adherence (based on refill compliance). Of the 184 eligible participants, 129 (70%) were less than 95% adherent. Variables independently associated with nonadherence included frequent heroin injection (adjusted odds ratio [AOR] = 2.6, 95% confidence interval [CI], 1.6-4.0), baseline CD4 count less than 200 cells/mm(3) (AOR = 2.5; 95% CI, 1.9-3.2), and poor treatment by health care professionals (AOR = 1.7; 95% CI, 1.2-3.0). Variables inversely associated with HAART nonadherence included attaining viral load suppression (AOR = 0.3; 95% CI, 0.2-0.5) and methadone maintenance therapy (AOR = 0.5; 95% CI, 0.4-0.9). Innovative strategies that address the social barriers facing marginalized populations are needed to support the long-term continuation of HAART.

Nonadherence to antiretroviral therapy among a community with endemic rates of injection drug use. Publishing Authors By Initials

K Shannon,T Kerr,C Lai,T Ishida,E Wood,JS Montaner,RS Hogg,MW Tyndall,

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Nonadherence to antiretroviral therapy among a community with endemic rates of injection drug use. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the International Association of Physic

VOLUME: 4

Page Numbers: 66-72

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ISSN: 1545-1097

DAY: 26

MONTH: Jul

YEAR: 2005

Nonadherence to antiretroviral therapy among a community with endemic rates of injection drug use. Information

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LANGUAGE: eng

NlmUniqueID: 101185740

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AFFILIATION: British Columbia Centre for Excellence in HIV/AIDS.

Country: United States

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MEDLINETA: J Int Assoc Physicians AIDS Ca

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