Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1.

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Abstract Text:

R Raininko,L Thelin,O Eeg-Olofsson,R Raininko,L Thelin,O Eeg-Olofsson,

The occurrence, localization and longitudinal course of non-neoplastic MRI abnormalities in children and adolescents with neurofibromatosis type 1 (NF 1) were studied. Thirty-five patients who satisfied the criteria for NF 1 underwent 114 MRI examinations. They were 9 months to 18 years old at their first examination, and 23 were examined more than once (2 - 11 times). The follow-up time varied from 3 months to 10 years (mean 4 years). Thirty-one patients (89%) showed focal high signal intensities on T2-weighted images in the cerebellum, brain stem, deep cerebral gray matter and, less frequently, in the cerebral white matter. Changes were also seen in 80% and 50% of the proton density-weighted and T1-weighted images, respectively. Newly appearing, growing, decreasing and disappearing lesions occurred contemporaneously and in all ages. New lesions still developed in the late teens. Three lesions showed temporary contrast enhancement. Five expansive lesions were found in four individuals without related clinical symptoms. Four of them receded during follow-up. These cases indicate that the differential diagnosis between neoplastic and non-neoplastic lesions is not clear. The results support the view that high T2-signal lesions are so common in NF 1 that they should be included as another criterion for the diagnosis.

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Publishing Authors By Initials

R Raininko,L Thelin,O Eeg-Olofsson,R Raininko,L Thelin,O Eeg-Olofsson,

For similar neoplasms: neoplasms by histologic type: neoplasms, nerve tissue: nerve sheath neoplasms: neurofibroma: neurofibromatoses: neurofibromatosis 1 research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, nerve tissue: nerve sheath neoplasms: neurofibroma: neurofibromatoses: neurofibromatosis 1 research

PUBMED ID PMID:

MEDLINE DATE:

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropediatrics

VOLUME: 32

Page Numbers: 225-30

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Oct

YEAR: 2001

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8101187

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Keywords Mesh Terms:

KEYWORDS: Neurofibromatosis 1

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1.

AFFILIATION: Department of Oncology, Radiology and Clinical Immunology, Section of Radiology, Uppsala University, Uppsala, Sweden. raili.raininko@radiol.uu.se

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neuropediatrics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1 Related Publications

• A 3-year follow-up of headache diagnoses and symptoms in Swedish schoolchildren.
• Headache in schoolchildren: agreement between different sources of information.
• Hypoglycemia and neurological disturbances in children with diabetes mellitus.
• Non-neoplastic brain abnormalities on MRI in children and adolescents with neurofibromatosis type 1.
• Prevalence of headache in Swedish schoolchildren, with a focus on tension-type headache.
• The development of the electroencephalogram in normal children and adolescents from the age of 1 through 21 years.
• [Not Available.]
• [Not Available.]