Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI.

Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI. Research Abstract Details 

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Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI. Abstract Text:

C Boulocher,E Chereul,J B Langlois,M Armenean,M E Duclos,E Viguier,T Roger,E Vignon,C Boulocher,E Chereul,J B Langlois,M Armenean,M E Duclos,E Viguier,T Roger,E Vignon,

OBJECTIVE: To develop a quantitative non-invasive in vivo three-dimensional (3D) high resolution (HR) micro-magnetic resonance imaging (muMRI) protocol to measure the medial tibial cartilage thickness (MT.ThC) in the normal rabbit and in the anterior cruciate ligament transection (ACLT) rabbit model of osteoarthritis and quantify the progression of MT.ThC. METHODS: The left knee of 10 control and 40 operated rabbits was imaged in vivo with a 7T muMRI system at 3 and 5 months after ACLT. A 3D fast low angle short (FLASH) fat-suppressed MRI protocol was implemented leading to 44x176mum(3) spatial resolution and to 44mum(3) isotropic voxel after cubic interpolation. Semi-automatic MT.ThC measurements were made in 3D, in four different locations, in vivo and longitudinally in both groups. At 5 months, gross macroscopy, visual analogical evaluation of the cartilage and histology were compared to the MR-based MT.ThC. RESULTS: At 3 and 5 months, the MT.ThC measured in the minimum interbone distance area was the thinnest MR-based MT.ThC. It was significantly lower in the operated group and among the four evaluated MT.ThC, it was the most discriminative between the normal and the operated groups (P<0.05). The MT.ThC measured in the minimum interbone distance area was also the most sensitive to change in the operated group (66.4% MT.ThC loss, P=0.003) while no significant changes were observed in the control group. CONCLUSION: Quantitative 3D HR muMRI allowed for non-invasive longitudinal MT.ThC measurements in four different locations in both the normal and the operated rabbits. We concluded the MT.ThC measured in the minimum interbone distance area reflected the severity of the disease and was the most effective to measure the progression of the medial tibial cartilage destruction.

Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI. Publishing Authors By Initials

C Boulocher,E Chereul,JB Langlois,M Armenean,ME Duclos,E Viguier,T Roger,E Vignon,C Boulocher,E Chereul,JB Langlois,M Armenean,ME Duclos,E Viguier,T Roger,E Vignon,

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Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Osteoarthritis and cartilage / OARS, Osteoarthriti

VOLUME: 15

Page Numbers: 1378-87

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ISSN: 1063-4584

DAY: 18

MONTH: 06

YEAR: 2007

Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Non-invasive in vivo quantification of the medial tibial cartilage thickness progression in an osteoarthritis rabbit model with quantitative 3D high resolution micro-MRI.

AFFILIATION: Université de Lyon, UR RTI2B, Lyon F-69003, France; Université de Lyon, Ecole Nationale Vétérinaire de Lyon (ENVL), Marcy l'Etoile, F-69280, France.

Country: England

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MEDLINETA: Osteoarthritis Cartilage

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