Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model.

Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Research Abstract Details 

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Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Abstract Text:

Jangwoen Lee,Jennifer Armstrong,Kelly Kreuter,Bruce J Tromberg,Matthew Brenner,

The objective of this study is to establish a cyanide toxicity animal model and to investigate the ability of broadband diffuse optical spectroscopy (DOS) to non-invasively monitor physiological changes that occur during the development of cyanide toxicity in a rabbit model. Broadband DOS combines multi-frequency frequency-domain photon migration (FDPM) with time-independent near-infrared spectroscopy (NIRS) to quantitatively measure bulk tissue absorption and scattering spectra between 600 nm and 1000 nm. Serum cyanide concentration and arterial and venous blood gas analysis at pre- and post-cyanide infusion were presented. To investigate the ability of DOS to non-invasively monitor physiologic changes occurring during development of CN toxicity, tissue concentrations of deoxyhemoglobin [Hb-R], oxyhemoglobin [Hb-O2], cytochrome c oxidase oxidized state [CcO_Ox] and reduced state [CcO_Re] were determined from absorption spectra acquired in 'real time' during cyanide infusions (NaCN 6 mg/60 ml normal saline) in six pathogen-free New Zealand white rabbits. During cyanide infusion, in vivo tissue oxygen saturation increased ( approximately 10%). In addition, broadband DOS was able to detect a concurrent increase in [CcO_Re] and decrease in [CcO_Ox]. Changes in tissue scattering properties in all six animals were detected during these events, confirming the need for DOS-based methods over traditional NIR spectroscopy to obtain accurate results.

Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Publishing Authors By Initials

J Lee,J Armstrong,K Kreuter,BJ Tromberg,M Brenner,

For similar investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, infrared research abstracts see: investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, infrared research

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Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological measurement

VOLUME: 28

Page Numbers: 1057-66

Journal Abbreviation:

ISSN: 0967-3334

DAY: 21

MONTH: 08

YEAR: 2007

Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Information

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LANGUAGE: eng

NlmUniqueID: 9306921

Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Keywords Mesh Terms:

KEYWORDS: Spectrophotometry, Infrared

MESH TERMS: methods

Chemical & Substance for Abstract: Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model. Information

Substance Name: Potassium Cyanide

Registry Number: 151-50-8

Grant and Affiliation Information for Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model.

AFFILIATION: Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA 92612-1475, USA. jangwl@uci.edu

Country: England

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MEDLINETA: Physiol Meas

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