Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway.

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Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway. Abstract Text:

Ziyun Du,Lai Wei,Aruna Murti,Susan R Pfeffer,Meiyun Fan,Chuan He Yang,Lawrence M Pfeffer,Ziyun Du,Lai Wei,Aruna Murti,Susan R Pfeffer,Meiyun Fan,Chuan He Yang,Lawrence M Pfeffer,

Type I interferons (IFNs) regulate diverse cellular functions by modulating the expression of IFN-stimulated genes (ISGs) through the activation of the well established signal transduction pathway of the Janus Kinase (JAK) and signal transducers and activators of transcription (STAT) proteins. Although the JAK-STAT signal transduction pathway is critical in mediating IFN's antiviral and antiproliferative activities, other signaling pathways are activated by IFNs and regulate cellular response to IFN. The NF-kappaB transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel IFN mediated signal pathway that leads to NF-kappaB activation and demonstrate that a subset of ISGs that play key roles in cellular response to IFN is regulated by NF-kappaB. This review focuses on the IFN-induced NF-kappaB activation pathway and the role of NF-kappaB in ISG expression, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease. J. Cell. Biochem. 102: 1087-1094, 2007. (c) 2007 Wiley-Liss, Inc.

Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway. Publishing Authors By Initials

Z Du,L Wei,A Murti,SR Pfeffer,M Fan,CH Yang,LM Pfeffer,Z Du,L Wei,A Murti,SR Pfeffer,M Fan,CH Yang,LM Pfeffer,

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Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cellular biochemistry

VOLUME: 102

Page Numbers: 1087-94

Journal Abbreviation: J. Cell. Biochem.

ISSN: 0730-2312

DAY: 1

MONTH: Dec

YEAR: 2007

Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, University of Tennessee Cancer Institute, Memphis, Tennessee 38163.

Country: United States

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MEDLINETA: J Cell Biochem

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