Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Research Abstract Details 

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Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Abstract Text:

J A McMahon,S Takada,L B Zimmerman,C M Fan,R M Harland,A P McMahon,

Embryonic patterning in vertebrates is dependent upon the balance of inductive signals and their specific antagonists. We show that Noggin, which encodes a bone morphogenetic protein (BMP) antagonist expressed in the node, notochord, and dorsal somite, is required for normal mouse development. Although Noggin has been implicated in neural induction, examination of null mutants in the mouse indicates that Noggin is not essential for this process. However, Noggin is required for subsequent growth and patterning of the neural tube. Early BMP-dependent dorsal cell fates, the roof plate and neural crest, form in the absence of Noggin. However, there is a progressive loss of early, Sonic hedgehog (Shh)-dependent ventral cell fates despite the normal expression of Shh in the notochord. Further, somite differentiation is deficient in both muscle and sclerotomal precursors. Addition of BMP2 or BMP4 to paraxial mesoderm explants blocks Shh-mediated induction of Pax-1, a sclerotomal marker, whereas addition of Noggin is sufficient to induce Pax-1. Noggin and Shh induce Pax-1 synergistically. Use of protein kinase A stimulators blocks Shh-mediated induction of Pax-1, but not induction by Noggin, suggesting that induction is mediated by different pathways. Together these data demonstrate that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite.

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Publishing Authors By Initials

JA McMahon,S Takada,LB Zimmerman,CM Fan,RM Harland,AP McMahon,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Genes & development

VOLUME: 12

Page Numbers: 1438-52

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 15

MONTH: May

YEAR: 1998

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711660

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Information

Substance Name: Cyclic AMP-Dependent Protein Kinases

Registry Number: EC 2.7.11.11

Grant and Affiliation Information for Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.

AFFILIATION: Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA.amcmahon.biosun.harvar d.edu

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: GM49346

ACRONYM: GM

MEDLINETA: Genes Dev

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