Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.

Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Research Abstract Details 

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Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Abstract Text:

Dong Hyun Kim,Do Yoon Kim,Young Choong Kim,Ji Wook Jung,Seungjoo Lee,Byung Hoon Yoon,Jae Hoon Cheong,Yeong Shik Kim,Sam Sik Kang,Kwang Ho Ko,Jong Hoon Ryu,Dong Hyun Kim,Do Yoon Kim,Young Choong Kim,Ji Wook Jung,Seungjoo Lee,Byung Hoon Yoon,Jae Hoon Cheong,Yeong Shik Kim,Sam Sik Kang,Kwang Ho Ko,Jong Hoon Ryu,

Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.

Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Publishing Authors By Initials

DH Kim,do Y Kim,YC Kim,JW Jung,S Lee,BH Yoon,JH Cheong,YS Kim,SS Kang,KH Ko,JH Ryu,DH Kim,do Y Kim,YC Kim,JW Jung,S Lee,BH Yoon,JH Cheong,YS Kim,SS Kang,KH Ko,JH Ryu,

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Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Life sciences

VOLUME: 80

Page Numbers: 1944-50

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ISSN: 0024-3205

DAY: 27

MONTH: 02

YEAR: 2007

Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Information

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LANGUAGE: eng

NlmUniqueID: 375521

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Grant and Affiliation Information for Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.

AFFILIATION: Department of Oriental Pharmaceutical Science and East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Republic of Korea.

Country: England

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MEDLINETA: Life Sci

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