Nocturnal hypertension in mice consuming a high fructose diet.

Nocturnal hypertension in mice consuming a high fructose diet. Research Abstract Details 

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Nocturnal hypertension in mice consuming a high fructose diet. Abstract Text:

Vera Farah,Khalid M Elased,Yanfang Chen,Mary P Key,Tatiana S Cunha,Maria Claudia Irigoyen,Mariana Morris,

OBJECTIVE: To investigate the effect of fructose consumption on the light/dark pattern of blood pressure, heart rate and autonomic neural function in mice. BACKGROUND: Insulin resistant diabetes is associated with hypertension and autonomic dysfunction. There is evidence that the increasing incidence of diabetes may be related to dietary changes, including consumption of high levels of fructose. DESIGN/METHODS: C57/BL mice, instrumented with radiotelemetric arterial catheters, were fed a control or high fructose diet (60%). Cardiovascular parameters measured were light/dark pattern of mean arterial pressure (MAP), heart rate (HR) and variability (time and frequency domain). We also measured plasma insulin, glucose, lipids and angiotensin II (Ang II) as well as glucose tolerance. In situ hybridization was used to measure brainstem expression of tyrosine hydroxylase (TH) and Ang AT1a mRNA. RESULTS: Fructose diet (8 weeks) produced an increase in MAP, variance and low frequency domain (14+/-3 vs. 33+/-4 mm Hg(2), variance and 10+/-2 vs. 26+/-4 mm Hg(2), LF, control vs. fructose, P<0.01). The changes occurred only at night, a period of activity for mice. Glucose tolerance was attenuated in the fructose group. Fructose also increased plasma cholesterol (80+/-1 vs. 126+/-2 mg/dl, control vs. fructose, P<0.05) and plasma Ang II (18+/-5 vs.65+/-12 pg/ml, control vs. fructose, P<0.05). Depressor responses to alpha(1)-adrenergic blockade with prasozin were augmented in fructose-fed mice. Using quantitative in situ hybridization, we found that Ang AT1a receptor and TH mRNA expression were significantly increased in the brainstem locus coeruleus. CONCLUSION: A high fructose diet in mice produced nocturnal hypertension and autonomic imbalance which may be related to activation of sympathetic and angiotensin systems.

Nocturnal hypertension in mice consuming a high fructose diet. Publishing Authors By Initials

V Farah,KM Elased,Y Chen,MP Key,TS Cunha,MC Irigoyen,M Morris,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

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MEDLINE DATE:

Nocturnal hypertension in mice consuming a high fructose diet. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Autonomic neuroscience : basic & clinical

VOLUME: 130

Page Numbers: 41-50

Journal Abbreviation:

ISSN: 1566-0702

DAY: 13

MONTH: 07

YEAR: 2006

Nocturnal hypertension in mice consuming a high fructose diet. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100909359

Nocturnal hypertension in mice consuming a high fructose diet. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: genetics

Chemical & Substance for Abstract: Nocturnal hypertension in mice consuming a high fructose diet. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Nocturnal hypertension in mice consuming a high fructose diet.

AFFILIATION: Boonshoft School of Medicine of Wright State University, Department of Pharmacology and Toxicology, Dayton, OH 45401, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: R01HL69319

ACRONYM: HL

MEDLINETA: Auton Neurosci

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