No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART.

No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART. Research Abstract Details 

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No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART. Abstract Text:

Masaaki Takahashi,Shiro Ibe,Yuichi Kudaka,Naoya Okumura,Atsushi Hirano,Tatsuo Suzuki,Naoto Mamiya,Motohiro Hamaguchi,Tsuguhiro Kaneda,Masaaki Takahashi,Shiro Ibe,Yuichi Kudaka,Naoya Okumura,Atsushi Hirano,Tatsuo Suzuki,Naoto Mamiya,Motohiro Hamaguchi,Tsuguhiro Kaneda,

The present study assessed the relationship between central nervous system (CNS) side effects and plasma concentrations of efavirenz (EFV) in Japanese HIV-1-infected patients. Subjects consisted of 69 HIV-1-infected patients (57 therapy-naive and 12 therapy-experienced patients) being treated using EFV in combination with other antiretroviral agents at the outpatient HIV clinic. Successful virological treatment was achieved in 61 patients. Eight patients discontinued EFV containing therapy because CNS symptoms did not resolve (four patients), EFV-specific mutations were detected (two patients), or skin rash was observed (two patients). Mean EFV plasma concentration for 61 effectively treated patients, measured at 15 h postdosing, was 2.42 microg/ml (range: 0.78-6.82 microg/ml). This EFV concentration range contributed to suppressed viral load in these Japanese patients. Adverse CNS effects were observed in 19 patients soon after therapy onset. These effects disappeared within 1 month except for four patients who suffered severe CNS side effects. Mean EFV plasma concentrations were not significantly different between subjects with (2.45 +/- 1.08 microg/ml) and without (2.42 +/- 1.40 microg/ml) CNS side effects. We concluded no correlation existed between the plasma EFV concentration and the emergence of CNS side effects in Japanese HIV-1-infected patients. Further investigations, enforced with the drug concentration measurement at earlier time points and more appropriate assessment of CNS symptoms, are required.

No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART. Publishing Authors By Initials

M Takahashi,S Ibe,Y Kudaka,N Okumura,A Hirano,T Suzuki,N Mamiya,M Hamaguchi,T Kaneda,M Takahashi,S Ibe,Y Kudaka,N Okumura,A Hirano,T Suzuki,N Mamiya,M Hamaguchi,T Kaneda,

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No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AIDS research and human retroviruses

VOLUME: 23

Page Numbers: 983-7

Journal Abbreviation: AIDS Res. Hum. Retroviruses

ISSN: 0889-2229

DAY: 29

MONTH: Aug

YEAR: 2007

No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART. Information

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LANGUAGE: eng

NlmUniqueID: 8709376

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Grant and Affiliation Information for No observable correlation between central nervous system side effects and EFV plasma concentrations in Japanese HIV type 1-infected patients treated with EFV containing HAART.

AFFILIATION: Department of Pharmacy, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hospital for AIDS Treatment and Research), Nagoya,Aichi, Japan.

Country: United States

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MEDLINETA: AIDS Res Hum Retroviruses

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