[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese]

[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese] Research Abstract Details 

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[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese] Abstract Text:

J Shi,C Ma,H Lao,R Feng,Y Guo,N Mu,Q Li,Y Tan,D Wang,

OBJECTIVE: To determine the effect of the pentanucleotide deletion polymorphism adjacent to a consensus splice site in intron 17 of alpha 2-macroglobulin(A2M) gene on the development of late-onset Alzheimer's disease (LOAD) in the Han Chinese in Guangzhou area. METHODS: A2M and apolipoprotein E genotypes were examined by polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) techniques in the patients(32 men and 65 women) with LOAD and age-matched healthy elderly Chinese subjects (57 men and 54 women). RESULTS: The A2M gene deletion allele frequency was 2.6% in the cases with LOAD and 2.7% in the controls. In the LOAD cases, the frequency of apoE-epsilon4 increased significantly (Z=3.32, P<0.01). ApoE-epsilon4 was associated with LOAD (RR=2.67, chi(2)=10.71, P<0.01) while the A2M deletion polymorphism was not associated with LOAD even the samples were stratified according to the presence of the apoE-epsilon4 allele. CONCLUSION: The above data demonstrate that there is no evidence for the association of A2M polymorphism with the development of LOAD in the Han Chinese population in Gaungzhou.

[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese] Publishing Authors By Initials

J Shi,C Ma,H Lao,R Feng,Y Guo,N Mu,Q Li,Y Tan,D Wang,

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[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 18

Page Numbers: 299-302

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 2

MONTH: Aug

YEAR: 2001

[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese] Information

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LANGUAGE: chi

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AFFILIATION: Department of Geriatrics, Guangzhou Psychiatric Hospital, Guangzhou, Guangdong 510370 P.R.China. shiand98@21cn.com

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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