No effect of C-reactive protein (CRP) haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation.

No effect of C-reactive protein (CRP) haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation. Research Abstract Details 

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No effect of C-reactive protein (CRP) haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation. Abstract Text:

Bernd ,Carsten A ,Bernd ,Stefan Farkas,Andreas A Schnitzbauer,Ute Hoffmann,Aiman Obed,Barbara T Murphy,Bernhard Banas,Bernhard K ,

Increased serum C-reactive protein (CRP) levels have been associated with all-cause and cardiovascular mortality after kidney transplantation. As genetic variations within the CRP gene determine CRP serum levels, we analyzed the association of both serum CRP levels, and post-transplant morbidity/mortality with CRP-genotypes/haplotypes. We determined CRP levels pretransplant, at 3 and 6 months post-transplant in 402 first kidney recipients, genotyped the three functionally distinct polymorphisms, and subsequently reconstructed the different haplotypes. Four different CRP-haplotypes were observed with a frequency >1%: CGC (33.3%), CGT (30.2%), CAT (29.7%) and GGT (6.8%). CRP levels pretransplantation or 3 and 6 months post-transplant were not different in patients with different CRP-haplotypes. Furthermore, no association of CRP-haplotypes/diplotypes was found with acute rejection, delayed graft function, all-cause mortality or cardiovascular events. In our renal transplant population, we found no association of CRP-haplotypes/diplotypes with either CRP levels or with post-transplant morbidity/mortality. In this inflammation-prone population, rather small genetically determined differences in serum CRP observed in normal populations presumably are overridden by background inflammation. Life long genetically determined increased serum CRP levels appear not to have an impact in our study, implying that CRP is more likely only a marker of current inflammation than a causative agent of cardiovascular morbidity and mortality.

No effect of C-reactive protein (CRP) haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation. Publishing Authors By Initials

B ,CA ,B ,S Farkas,AA Schnitzbauer,U Hoffmann,A Obed,BT Murphy,B Banas,BK ,

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No effect of C-reactive protein (CRP) haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplant international : official journal of the

VOLUME: 21

Page Numbers: 452-8

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ISSN: 0934-0874

DAY: 4

MONTH: 02

YEAR: 2008

No effect of C-reactive protein (CRP) haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 8908516

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AFFILIATION: Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany, and Division of Nephrology, Mount Sinai School of Medicine, New York, NY, USA.

Country: Germany

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MEDLINETA: Transpl Int

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