No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia.

No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia. Research Abstract Details 

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No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia. Abstract Text:

Robert Philibert,Tracy Gunter,Nancy Hollenbeck,William J Adams,Phillip Bohle,Hans Packer,Harinder Sandhu,

Some serological and genetic studies have suggested that alterations in folate metabolism are associated with increased vulnerability to schizophrenia. In particular, these findings are most striking for the role of a putatively functional variant (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene. To test the hypothesis that the T allele and the TT genotype are risk factors for psychosis, we genotyped the C677T polymorphism in 206 participants with schizophrenia or schizoaffective disorder and 359 participants from a population control sample. Neither the T allele nor the TT genotype was associated with increased risk for schizophrenia. These results do not support a role for the C677T MTHFR variant in schizophrenia.

No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia. Publishing Authors By Initials

R Philibert,T Gunter,N Hollenbeck,WJ Adams,P Bohle,H Packer,H Sandhu,

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No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychiatric genetics

VOLUME: 16

Page Numbers: 221-3

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ISSN: 0955-8829

DAY: 3

MONTH: Oct

YEAR: 2006

No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia.

AFFILIATION: Department of Psychiatry, The University of Iowa, Psychiatry Research/MEB, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.edu

Country: England

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MEDLINETA: Psychiatr Genet

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