No association between chromosome-18 markers and lithium-responsive affective disorders.

No association between chromosome-18 markers and lithium-responsive affective disorders. Research Abstract Details 

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No association between chromosome-18 markers and lithium-responsive affective disorders. Abstract Text:

An allelic association study of excellent responders to lithium was conducted with a candidate gene (Golf, a G-protein receptor gene) and five other chromosome-18p markers. Golf is of special interest because it maps to a region of chromosome 18 where two independent groups (Berrettini et al., 1994; Stine et al., 1995) have found linkage to bipolar disorder. It has been proposed that G proteins are involved in the pathogenesis of bipolar disorder, and lithium, an effective prophylactic agent, is known to impair G-protein activation. To reduce heterogeneity--a common obstacle to genetic investigation--only patients who showed excellent response to lithium prophylaxis were studied. Fifty-five genetically unrelated excellent responders to lithium prophylaxis were compared with 94 normal subjects of similar ethnic background. The groups did not differ in either allele or genotype frequency for the tested markers. The data do not support the hypothesis that the tested loci confer a major susceptibility for affective disorders.

No association between chromosome-18 markers and lithium-responsive affective disorders. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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No association between chromosome-18 markers and lithium-responsive affective disorders. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 63

Page Numbers: 17-23

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 26

MONTH: Jun

YEAR: 1996

No association between chromosome-18 markers and lithium-responsive affective disorders. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911385

No association between chromosome-18 markers and lithium-responsive affective disorders. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: genetics

Chemical & Substance for Abstract: No association between chromosome-18 markers and lithium-responsive affective disorders. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for No association between chromosome-18 markers and lithium-responsive affective disorders.

AFFILIATION: Centre for Research in Neuroscience, Montreal General Hospital, Canada.

Country: IRELAND

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MEDLINETA: Psychiatry Res

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