No age-related cell loss in three retinal nuclear layers of the Long-Evans rat.

No age-related cell loss in three retinal nuclear layers of the Long-Evans rat. Research Abstract Details 

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No age-related cell loss in three retinal nuclear layers of the Long-Evans rat. Abstract Text:

Lixia Feng,Zhaoxia Sun,Hui Han,Yifeng Zhou,Ming Zhang,Lixia Feng,Zhaoxia Sun,Hui Han,Yifeng Zhou,Ming Zhang,

The retina mainly contains ganglion, bipolar and photoreceptor cells which are distributed in the ganglion cell layer (GCL), inner nuclear layer (INL) and outer nuclear layer (ONL), respectively. Whether there is an age-related loss of these retinal cells remains not well understood. Cell density and the total number of cells were two commonly used measures to evaluate such age-related changes in most previous studies and provided controversial conclusions. The use of density measures as decisive data is problematic because the total area of the retina was expanded in aging, whereas the application of the total number of cells was limited for assessing ganglion cells. In this study, thus, we wanted to test whether there is an age-related cell loss in the GCL, INL and ONL and if so, whether such a loss is correlated to the convergence ratio of these cells. We used stereological procedures to quantify the total number of cells in the three retinal nuclear layers in six young and six aged Long-Evans rats. We found that during aging, the total volume of the retina remained unchanged, but the retina became thinner. There was no cell loss in each individual nuclear layer, and the ratio of the ONL to INL to GCL was preserved.

No age-related cell loss in three retinal nuclear layers of the Long-Evans rat. Publishing Authors By Initials

L Feng,Z Sun,H Han,Y Zhou,M Zhang,L Feng,Z Sun,H Han,Y Zhou,M Zhang,

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MEDLINE DATE: 2007 Nov-Dec

No age-related cell loss in three retinal nuclear layers of the Long-Evans rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Visual neuroscience

VOLUME: 24

Page Numbers: 799-803

Journal Abbreviation: Vis. Neurosci.

ISSN: 0952-5238

DAY: 20

MONTH: 12

YEAR: 2007

No age-related cell loss in three retinal nuclear layers of the Long-Evans rat. Information

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LANGUAGE: eng

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Grant and Affiliation Information for No age-related cell loss in three retinal nuclear layers of the Long-Evans rat.

AFFILIATION: Department of Anatomy, Anhui Medical University, Hefei, P.R. ChinaDepartment of Ophthalmology, Anhui Medical University, Hefei, P.R. China.

Country: England

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MEDLINETA: Vis Neurosci

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