NMR studies of dynamics in RNA and DNA by 13C relaxation.

NMR studies of dynamics in RNA and DNA by 13C relaxation. Research Abstract Details 

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NMR studies of dynamics in RNA and DNA by 13C relaxation. Abstract Text:

Zahra Shajani,Gabriele Varani,

RNA and DNA molecules experience motions on a wide range of time scales, ranging from rapid localized motions to much slower collective motions of entire helical domains. The many functions of RNA in biology very often require this molecule to change its conformation in response to biological signals in the form of small molecules, proteins or other nucleic acids, whereas local motions in DNA may facilitate protein recognition and allow enzymes acting on DNA to access functional groups on the bases that would otherwise be buried in Watson-Crick base pairs. Although these statements make a compelling case to study the sequence dependent dynamics in nucleic acids, there are few residue-specific studies of nucleic acid dynamics. Fortunately, NMR studies of dynamics of nucleic acids and nucleic acids-protein complexes are gaining increased attention. The aim of this review is to provide an update of the recent progress in studies of nucleic acid dynamics by NMR based on the application of solution relaxation techniques.

NMR studies of dynamics in RNA and DNA by 13C relaxation. Publishing Authors By Initials

Z Shajani,G Varani,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

PUBMED ID PMID:

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NMR studies of dynamics in RNA and DNA by 13C relaxation. Journal Published:

PUBLICATION TYPE: Review

Journal: Biopolymers

VOLUME: 86

Page Numbers: 348-59

Journal Abbreviation: Biopolymers

ISSN: 0006-3525

DAY: 3

MONTH: 12

YEAR: 2007

NMR studies of dynamics in RNA and DNA by 13C relaxation. Information

Number of References: 81

LANGUAGE: eng

NlmUniqueID: 372525

NMR studies of dynamics in RNA and DNA by 13C relaxation. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: chemistry

Chemical & Substance for Abstract: NMR studies of dynamics in RNA and DNA by 13C relaxation. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for NMR studies of dynamics in RNA and DNA by 13C relaxation.

AFFILIATION: Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM58914

ACRONYM: GM

MEDLINETA: Biopolymers

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