NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases.

NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Research Abstract Details 

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NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Abstract Text:

U Deva Priyakumar,Alexander D Mackerell,

Molecular dynamics simulations were performed to investigate GC and AT base opening events in DNA. Calculated equilibrium constants between the base open (or flipped) and closed states were shown to be in good agreement with experimental data from NMR imino proton exchange experiments. Analysis of the computed results indicates that the equilbrium constants are dominated by the opening of the A and G bases in the AT and GC base pairs, respectively. Thus, the present results predict that NMR imino proton exchange experiments of base opening are primarily monitoring the opening of purine bases.

NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Publishing Authors By Initials

UD Priyakumar,AD Mackerell,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: purines: thioguanine research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: purines: thioguanine research

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NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 678-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 25

MONTH: Jan

YEAR: 2006

NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Keywords Mesh Terms:

KEYWORDS: Thioguanine

MESH TERMS: chemistry

Chemical & Substance for Abstract: NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for NMR imino proton exchange experiments on duplex DNA primarily monitor the opening of purine bases.

AFFILIATION: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM51501

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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