NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.

NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Research Abstract Details 

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NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Abstract Text:

Ewa Poleszak,Piotr Wla?,Ewa Kedzierska,Dorota Nieoczym,Andrzej ,Sylwia Fidecka,Andrzej Pilc,Gabriel Nowak,

Antidepressant-like activity of magnesium in forced swim test (FST) was demonstrated previously. Also, enhancement of such activity by joint administration of magnesium and antidepressants was shown. However, the mechanism(s) involved in such activity remain to be established. In the present study we examined the involvement of NMDA/glutamate pathway in the magnesium activity in FST in mice. In the present study we investigated the effect of NMDA agonists on magnesium-induced activity in FST and the influence of NMDA antagonists with sub-effective doses of magnesium in this test. Magnesium-induced antidepressant-like activity was antagonized by N-methyl-d-aspartic acid (NMDA). Moreover, low, ineffective doses of NMDA antagonists (CGP 37849, L-701,324, d-cycloserine, and MK-801) administered together with low and ineffective doses of magnesium exhibit significant reduction of immobility time in FST. The active in FST doses of examined agents did not alter the locomotor activity (with an exception of increased activity induced by MK-801). The present study indicates the involvement of NMDA/glutamate pathway in the antidepressant-like activity of magnesium in mouse FST and further suggests antidepressant properties of magnesium.

NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Publishing Authors By Initials

E Poleszak,P Wla?,E Kedzierska,D Nieoczym,A ,S Fidecka,A Pilc,G Nowak,

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NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 88

Page Numbers: 158-64

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 10

MONTH: 08

YEAR: 2007

NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmacology and Pharmacodynamics, Skubiszewski Medical University of Lublin, Staszica 4, PL 20-081 Lublin, Poland. ewa.poleszak@am.lublin.pl

Country: United States

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MEDLINETA: Pharmacol Biochem Behav

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