Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression.

Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Research Abstract Details 

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Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Abstract Text:

Sarah A Hutchinson,Sarah E Cheesman,Laura A Hale,Jason Q Boone,Judith S Eisen,

The ability of animals to carry out their normal behavioral repertoires requires exquisitely precise matching between specific motoneuron subtypes and the muscles they innervate. However, the molecular mechanisms that regulate motoneuron subtype specification remain unclear. Here, we use individually identified zebrafish primary motoneurons to describe a novel role for Nkx6 and Islet1 proteins in the specification of vertebrate motoneuron subtypes. We show that zebrafish primary motoneurons express two related Nkx6 transcription factors. In the absence of both Nkx6 proteins, the CaP motoneuron subtype develops normally, whereas the MiP motoneuron subtype develops a more interneuron-like morphology. In the absence of Nkx6 function, MiPs exhibit normal early expression of islet1, which is required for motoneuron formation; however, they fail to maintain islet1 expression. Misexpression of islet1 RNA can compensate for loss of Nkx6 function, providing evidence that Islet1 acts downstream of Nkx6. We suggest that Nkx6 proteins regulate MiP development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development.

Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Publishing Authors By Initials

SA Hutchinson,SE Cheesman,LA Hale,JQ Boone,JS Eisen,

For similar proteins: fish proteins: zebrafish proteins research abstracts see: proteins: fish proteins: zebrafish proteins research

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Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 1671-7

Journal Abbreviation:

ISSN: 0950-1991

DAY: 21

MONTH: 03

YEAR: 2007

Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Keywords Mesh Terms:

KEYWORDS: Zebrafish Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Information

Substance Name: insulin gene enhancer binding protein Is

Registry Number: 0

Grant and Affiliation Information for Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression.

AFFILIATION: Institute of Neuroscience, 1254 University of Oregon, Eugene OR 97403, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS23915

ACRONYM: NS

MEDLINETA: Development

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