Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Research Abstract Details 

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Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Abstract Text:

Asif K Mustafa,Manish Kumar,Balakrishnan Selvakumar,Gary P H Ho,Jeffrey T Ehmsen,Roxanne K Barrow,L Mario Amzel,Solomon H Snyder,

Serine racemase (SR) generates D-serine, a coagonist with glutamate at NMDA receptors. We show that SR is physiologically S-nitrosylated leading to marked inhibition of enzyme activity. Inhibition involves interactions with the cofactor ATP reflecting juxtaposition of the ATP-binding site and cysteine-113 (C113), the site for physiological S-nitrosylation. NMDA receptor physiologically enhances SR S-nitrosylation by activating neuronal nitric-oxide synthase (nNOS). These findings support a model whereby postsynaptic stimulation of nitric-oxide (NO) formation feeds back to presynaptic cells to S-nitrosylate SR and decrease D-serine availability to postsynaptic NMDA receptors.

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Publishing Authors By Initials

AK Mustafa,M Kumar,B Selvakumar,GP Ho,JT Ehmsen,RK Barrow,LM Amzel,SH Snyder,

For similar amino acids, peptides, and proteins: amino acids: amino acids, neutral: serine research abstracts see: amino acids, peptides, and proteins: amino acids: amino acids, neutral: serine research

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MEDLINE DATE:

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 2950-5

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 9

MONTH: 02

YEAR: 2007

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Keywords Mesh Terms:

KEYWORDS: Serine

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Information

Substance Name: serine racemase

Registry Number: EC 5.1.1.16

Grant and Affiliation Information for Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.

AFFILIATION: Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH 18501

ACRONYM: MH

MEDLINETA: Proc Natl Acad Sci U S A

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