Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation.

Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation. Research Abstract Details 

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Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation. Abstract Text:

The preparation, characterization, and NO-releasing properties of metal complexes derived from N-aminoethylpiperazine-N-diazeniumdiolate (HPipNONO), [Cu(PipNONO)Cl] and [Ni(PipNONO)Cl], and the Ni(II) complex derived from the Schiff base between HPipNONO and salicylaldehyde, [Ni(SalPipNONO)], are described. Compounds [Cu(PipNONO)Cl] and [Ni(SalPipNONO)] release NO at a much slower rate than HPipNONO in aqueous buffer in the pH range between 6.8 and 8.0. The kinetics of NO release by [Ni(SalPipNONO)] is complex, with an apparent stepwise release of NO molecules. Both [Cu(PipNONO)Cl] and [Ni(SalPipNONO)] are effective vasorelaxant agents of precontracted rabbit aorta rings, and are active in the nM concentration range. In addition, these complexes promote the proliferation of endothelial cells. Both vascular activities were inhibited by a specific inhibitor of guanylate cyclase, suggesting the involvement of the cGMP pathway. In all biological assays, the reference agent sodium nitroprusside was shown to be 10-1000-fold less potent than the two metal-NONOates.

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Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: ChemMedChem

VOLUME: 3

Page Numbers: 1039-47

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ISSN: 1860-7187

DAY: 17

MONTH: Jul

YEAR: 2008

Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation. Information

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LANGUAGE: eng

NlmUniqueID: 101259013

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Grant and Affiliation Information for Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation.

AFFILIATION: Sezione di Farmacologia, Dipartimento di Biologia Molecolare, Università di Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Country: Germany

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MEDLINETA: ChemMedChem

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