Nitric oxide levels in rat hypothalamus are increased by restraint stress and decreased by biting.

Nitric oxide levels in rat hypothalamus are increased by restraint stress and decreased by biting. Research Abstract Details 

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Nitric oxide levels in rat hypothalamus are increased by restraint stress and decreased by biting. Abstract Text:

Shinjiro Miyake,Shun-Suke Takahashi,Fumihiko Yoshino,Kazuo Todoki,Kenichi Sasaguri,Sadao Sato,Masaichi-Chang-il Lee,Shinjiro Miyake,Shun-Suke Takahashi,Fumihiko Yoshino,Kazuo Todoki,Kenichi Sasaguri,Sadao Sato,Masaichi-Chang-il Lee,

Mastication, which includes biting, is of great importance not only for the intake of food but also for the mental, physical and physiological functioning of the body. For example, biting suppresses the stress response. Although biting and nitric oxide (NO) appear to modulate brain dynamics during stress, the underlying mechanisms have not been elucidated. In this study, we examined the effect of biting during restraint stress on NO levels in the rat hypothalamus. To this end, we used NO-selective electrodes that were calibrated by electron spin resonance (ESR) spectroscopy. We implanted the electrodes and probes for perfusion of solutions into the brain of rats, near the hypothalamus. Saline containing 10 mM N-nitro-L-arginine methyl ester (L-NAME), which is one of the most commonly used inhibitors of nitric oxide synthase (NOS), was employed as the perfusate. L-NAME prevented increases in NO levels in the rat hypothalamus that were induced by restraint stress and biting. Hypothalamic NO levels in rats under restraint stress for 180 min were increased above levels observed in unrestrained control rats. The increase in hypothalamic NO (from 2.123 muM to 4.760 muM) during restraint stress was reduced after biting for 30 min. The decay rate of NO levels after biting was -0.584 pA/min (-0.071 muM/min). We conclude that: (i) it is possible to evaluate NO levels in vivo in rat brain; (ii) NO levels are increased by restraint stress; and (iii) this increase is prevented by biting behavior.

Nitric oxide levels in rat hypothalamus are increased by restraint stress and decreased by biting. Publishing Authors By Initials

S Miyake,SS Takahashi,F Yoshino,K Todoki,K Sasaguri,S Sato,MC Lee,S Miyake,SS Takahashi,F Yoshino,K Todoki,K Sasaguri,S Sato,MC Lee,

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Nitric oxide levels in rat hypothalamus are increased by restraint stress and decreased by biting. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Redox report : communications in free radical rese

VOLUME: 13

Page Numbers: 31-9

Journal Abbreviation: Redox Rep.

ISSN: 1743-2928

DAY: 20

MONTH: 02

YEAR: 2008

Nitric oxide levels in rat hypothalamus are increased by restraint stress and decreased by biting. Information

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LANGUAGE: eng

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AFFILIATION: Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Kanagawa, Japan.

Country: England

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MEDLINETA: Redox Rep

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