Nitric oxide: involvement in the effects of anesthetic agents.

Nitric oxide: involvement in the effects of anesthetic agents. Research Abstract Details 

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Nitric oxide: involvement in the effects of anesthetic agents. Abstract Text:

Noboru Toda,Hiroshi Toda,Yoshio Hatano,Noboru Toda,Hiroshi Toda,Yoshio Hatano,

There has been an explosive increase in the amount of interesting information about the physiologic and pathophysiologic roles of nitric oxide in cardiovascular, nervous, and immune systems. The possible involvement of the nitric oxide-cyclic guanosine monophosphate pathway in the effects of anesthetic agents has been the focus of many investigators. Relaxations of cerebral and peripheral arterial smooth muscle as well as increases in cerebral and other regional blood flows induced by anesthetic agents are mediated mainly via nitric oxide released from the endothelium and/or the nitrergic nerve and also via prostaglandin I2 or endothelium-derived hyperpolarizing factor. Preconditioning with volatile anesthetics protects against ischemia-reperfusion-induced myocardial dysfunction and cell death or neurotoxicity, possibly through nitric oxide release. Inhibition of nitric oxide synthase decreases the anesthetic requirement. Involvement of nitric oxide in the effects of volatile, intravenous, and local anesthetics differs. This review article includes a summary of information about the sites and mechanisms by which various anesthetic agents interact with the nitric oxide-cyclic guanosine monophosphate system.

Nitric oxide: involvement in the effects of anesthetic agents. Publishing Authors By Initials

N Toda,H Toda,Y Hatano,N Toda,H Toda,Y Hatano,

For similar inorganic chemicals: free radicals: nitric oxide research abstracts see: inorganic chemicals: free radicals: nitric oxide research

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Nitric oxide: involvement in the effects of anesthetic agents. Journal Published:

PUBLICATION TYPE: Review

Journal: Anesthesiology

VOLUME: 107

Page Numbers: 822-42

Journal Abbreviation: Anesthesiology

ISSN: 0003-3022

DAY: 15

MONTH: Nov

YEAR: 2007

Nitric oxide: involvement in the effects of anesthetic agents. Information

Number of References: 229

LANGUAGE: eng

NlmUniqueID: 1300217

Nitric oxide: involvement in the effects of anesthetic agents. Keywords Mesh Terms:

KEYWORDS: Nitric Oxide

MESH TERMS: physiology

Chemical & Substance for Abstract: Nitric oxide: involvement in the effects of anesthetic agents. Information

Substance Name: Cyclic GMP

Registry Number: 7665-99-8

Grant and Affiliation Information for Nitric oxide: involvement in the effects of anesthetic agents.

AFFILIATION: Shiga University of Medical Science, Shiga, Japan. n.toda.toyama-bldg@orion.ocn.ne.jp

Country: United States

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MEDLINETA: Anesthesiology

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