Nitrative stress in refractory asthma.

Nitrative stress in refractory asthma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Nitrative stress in refractory asthma. Abstract Text:

Hisatoshi Sugiura,Yuichi Komaki,Akira Koarai,Masakazu Ichinose,

BACKGROUND: Most asthma is mild and moderate and can be well controlled by low-dose inhaled steroid with or without bronchodilators. However, 5% to 10% of patients with asthma have more troublesome disease despite using such medication. Recent reports showed that nitrative stress induced tissue remodeling in vitro, which is associated with a component of refractoriness in asthma. However, there is no report that nitrative stress is involved in refractory asthma. OBJECTIVE: The aim of this study is to evaluate whether patients with refractory asthma have more nitrative stress. METHODS: Ten healthy subjects, 10 patients with well-controlled asthma, and 8 patients with refractory asthma took part in the current study. Exhaled nitric oxide, xanthine oxidase activity in the supernatant of the sputum, immunostaining for the inducible type of nitric oxide synthase, and 3-nitrotyrosine in induced sputum from the subjects were assessed. RESULTS: All nitrative markers including exhaled nitric oxide (P < .01), immunopositivities for inducible nitric oxide synthase (P < .01), xanthine oxidase activities (P < .01), and 3-nitrotyrosine (P < .01) in sputum from the refractory asthma group were enhanced compared with the well-controlled group. All these nitrative markers in the sputum had a significant negative correlation with the %FEV(1) values (P < .01). CONCLUSION: These results suggested that patients with refractory asthma have more nitrative stress in their airways compared with patients with well-controlled asthma.

Nitrative stress in refractory asthma. Publishing Authors By Initials

H Sugiura,Y Komaki,A Koarai,M Ichinose,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Nitrative stress in refractory asthma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of allergy and clinical immunology

VOLUME: 121

Page Numbers: 355-60

Journal Abbreviation: J. Allergy Clin. Immunol.

ISSN: 1097-6825

DAY: 26

MONTH: 12

YEAR: 2007

Nitrative stress in refractory asthma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1275002

Nitrative stress in refractory asthma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Nitrative stress in refractory asthma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Nitrative stress in refractory asthma.

AFFILIATION: Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Allergy Clin Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Nitrative stress in refractory asthma Related Publications

• A long-term survivor after aggressive treatment for tracheal adenoid cystic carcinoma: a case report.
• Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice.
• Baroreflex control of muscle sympathetic nerve activity: Activated muscle metaboreflex in humans: 210: 1:05 PM-1:30 PM.
• Bundle-like assemblies of cadmium hydroxide nanostrands and anionic dyes.
• Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta(2)-agonists.
• Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung.
• Developmentally regulated expression of matrix metalloproteinases during fetal rat colon morphogenesis.
• Effects of glycosylation on swimming ability and flagellar polymorphic transformation in Pseudomonas syringae pv. tabaci 6605.
• Efficacy and safety of formoterol in Japanese patients with COPD.
• Expression and release of the a and b subunits for human coagulation factor XIII in baby hamster kidney (BHK) cells.
• Flagellin glycans from two pathovars of Pseudomonas syringae contain rhamnose in D and L configurations in different ratios and modified 4-amino-4,6-dideoxyglucose.
• Foam films obtained with ionic liquid.
• High-resolution MR cisternography of the cerebellopontine angle: 2D versus 3D fast spin-echo sequences.
• IF YOU HAVE A CASE AGAINST YOU.
• Improvement of pulmonary function and dyspnea by tiotropium in COPD patients using a transdermal beta(2)-agonist.
• Increased expression of tyrosine hydroxylase and anomalous neurites in catecholaminergic neurons of ATF-2 null mice.
• Isolation of 8'-Phosphate Ester Derivatives of Amicoumacins: Structure-activity Relationship of Hydroxy Amino Acid Moiety.
• MR imaging of the enlarged endolymphatic duct and sac syndrome by use of a 3D fast asymmetric spin-echo sequence: volume and signal-intensity measurement of the endolymphatic duct and sac and area measurement of the cochlear modiolus.
• Modulation of defense signal transduction by flagellin-induced WRKY41 transcription factor in Arabidopsis thaliana.
• Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase.
• Multiple novel transcripts for apolipoprotein(a)-related gene II generated by alternative splicing in tissue- and cell type-specific manners.
• Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature.
• Nitrative stress in refractory asthma.
• ON THE ISOLATION AND IDENTIFICATION OF S-METHYLCYSTEINE FROM HUMAN URINE.
• Oxidative and nitrative stress in bronchial asthma.
• Potent induction therapy with interferon and ribavirin combination therapy does not achieve a higher sustained virological response rate in chronic hepatitis C with genotype 1b and high hepatitis C virus RNA level.
• Prevalence of COPD in primary care clinics: correlation with non-respiratory diseases.
• Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4alpha and ubiquitous factor Sp1.
• Subcellular distribution of mitochondrial ribosomal RNA in the mouse oocyte and zygote.
• [Pulmonary metastatic carcinoma of the rectum growing extensively in the bronchial lumen--a case report]