Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.

Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Research Abstract Details 

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Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Abstract Text:

Q Fan,F Gao,L Zhang,T A Christopher,B L Lopez,X L Ma,Q Fan,F Gao,L Zhang,T A Christopher,B L Lopez,X L Ma,Q Fan,F Gao,L Zhang,T A Christopher,B L Lopez,X L Ma,

OBJECTIVES: This study examined the effects of nitrate tolerance (NT) on myocardial ischemia reperfusion (MI/R) injury and elucidated the potential mechanisms involved. Furthermore, the effects of GSH on postischemic myocardial apoptosis in NT rats were investigated. METHODS AND RESULTS: Male Sprague-Dawley rats were randomized to receive nitroglycerin (60 microg/kg/h) or saline for 12 h followed by 40 min of MI and 4 h of reperfusion. Myocardial apoptosis, infarct size, nitrotyrosine formation, plasma CK and LDH activity, and cardiac function were determined. MI/R resulted in significant apoptotic cell death, which was further increased in animals with NT. In addition, NT further increased plasma CK and LDH activity, enlarged infarct size, and impaired cardiac functional recovery after ischemia. Myocardial nitrotyrosine, a footprint for cytotoxic reactive nitrogen species formation, was further enhanced in the NT heart after MI/R. Treatment of NT animals with exogenous GSH inhibited nitrotyrosine formation, reduced apoptosis, decreased infarct size, and improved cardiac functional recovery. CONCLUSION: Our results demonstrate that nitrate tolerance markedly enhances MI/R injury and that increased peroxynitrite formation likely plays a role in this pathologic process. In addition, our results suggest that GSH could decrease peroxynitrite formation and reduce MI/R injury in nitrate tolerant hearts.

Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Publishing Authors By Initials

Q Fan,F Gao,L Zhang,TA Christopher,BL Lopez,XL Ma,Q Fan,F Gao,L Zhang,TA Christopher,BL Lopez,XL Ma,Q Fan,F Gao,L Zhang,TA Christopher,BL Lopez,XL Ma,

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Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Apoptosis : an international journal on programmed

VOLUME: 10

Page Numbers: 1235-42

Journal Abbreviation: Apoptosis

ISSN: 1360-8185

DAY: 23

MONTH: Dec

YEAR: 2005

Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Information

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LANGUAGE: eng

NlmUniqueID: 9712129

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Grant and Affiliation Information for Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.

AFFILIATION: Department of Physiology, Fourth Military Medical University, Xi-An, PR China.

Country: United States

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MEDLINETA: Apoptosis

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