Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Abstract Text:

Guilarte,Ming-Kai Chen,Jennifer L McGlothan,Tatyana Verina,Dean F Wong,Yun Zhou,Mohab Alexander,Charles A Rohde,Tore Syversen,Emmanuel Decamp,Amy Jo Koser,Stephanie Fritz,Heather Gonczi,David W Anderson,Jay S Schneider,

We tested the hypothesis that movement abnormalities induced by chronic manganese (Mn) exposure are mediated by dysfunction of the nigrostriatal dopamine system in the non-human primate striatum. Motor function and general activity of animals was monitored in parallel with chronic exposure to Mn and Positron Emission Tomography (PET) studies of in vivo dopamine release, dopamine transporters and dopamine receptors in the striatum. Analysis of metal concentrations in whole blood and brain was obtained and post-mortem analysis of brain tissue was used to confirm the in vivo PET findings. Chronic Mn exposure resulted in subtle motor function deficits that were associated with a marked decrease of in vivo dopamine release in the absence of a change in markers of dopamine (DA) terminal integrity or dopamine receptors in the striatum. These alterations in nigrostriatal DA system function were observed at blood Mn concentrations within the upper range of environmental, medical and occupational exposures in humans. These findings show that Mn-exposed non-human primates that exhibit subtle motor function deficits have an apparently intact but dysfunctional nigrostriatal DA system and provide a novel mechanism of Mn effects on the dopaminergic system.

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Publishing Authors By Initials

TR Guilarte,MK Chen,JL McGlothan,T Verina,DF Wong,Y Zhou,M Alexander,CA Rohde,T Syversen,E Decamp,AJ Koser,S Fritz,H Gonczi,DW Anderson,JS Schneider,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

PUBMED ID PMID:

MEDLINE DATE:

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental neurology

VOLUME: 202

Page Numbers: 381-90

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 22

MONTH: 08

YEAR: 2006

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370712

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.

AFFILIATION: Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. tguilart@jhsph.edu

Country: United States

AGENCY: United States NIEHS

GRANT: ES10975

ACRONYM: ES

MEDLINETA: Exp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates Related Publications

• A superconductive undulator with a period length of 3.8 mm.
• Abstinence and acceptance? The problematic relationship between the German abstinence paradigm, low-threshold oriented drug work, and methadone.
• Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli.
• Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila.
• All my rights.
• Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells.
• Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes.
• Calcium transients and intramembrane charge movement in skeletal muscle fibres.
• Cell size and Cln-Cdc28 complexes mediate entry into meiosis by modulating cell growth.
• Chest CT findings in pediatric Wegener's granulomatosis.
• Development of ATD Installation Procedures Based on Rear-Seat Occupant Postures.
• Does attention alter appearance?
• Dynamic modulation of upper airway function during sleep: a novel single-breath method.
• Effect of electrostatic interactions on binding and retention of DNA oligomers to PNA liposomes assessed by FRET measurements.
• Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys.
• Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs.
• Estimating infant head injury criteria and impact response using crash reconstruction and finite element modeling.
• Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study.
• Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer.
• Influence of day of collection on recovery rate in mature cycling mares.
• Influence of intensive embryo collection on subsequent embryo production.
• Influence of vesicle curvature on fluorescence relaxation kinetics of fluorophores.
• Metabolic and hormonal control of the desire for food and sex: implications for obesity and eating disorders.
• Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.
• Perceived barriers to walking for physical activity.
• Shigella as a foodborne pathogen and current methods for detection in food.
• The effects of tethering rear -facing child restraint systems on atd responses.
• The tolerance of the human hip to dynamic knee loading.
• [Evidence-based guidelines - what is the present situation?]
• [Innovative imaging in urology: fascination and future : Yesterday, today, and tomorrow.]