Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus.

Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Research Abstract Details 

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Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Abstract Text:

J Buee,J M Deniau,G Chevalier,

In the rat, the highly active GABAergic neurons of the substantia nigra pars reticulata (SNR) are known to exert a tonic inhibitory influence on cells in the ventral medial thalamic nucleus (VM). Considering that this nucleus is involved in the transfer of cerebellar signals towards motor cortex, we investigated the role played by SNR in that transmission. For this purpose we examined how changes in nigral background activity are reflected in the reactivity of VM cells to their cerebellar input. We report here that a GABA induced nigral pause increases the efficacy of cerebellar afferent volleys in VM, whereas an increase of nigral background by bicuculline, interrupts cerebello-thalamo-cortical transmission. It is concluded that nigrothalamic neurons subserve a permanent gating of cerebello-thalamo-cortical transmission in VM.

Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Publishing Authors By Initials

J Buee,JM Deniau,G Chevalier,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 65

Page Numbers: 241-4

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ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1986

Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus. Information

Substance Name: gamma-Aminobutyric Acid

Registry Number: 56-12-2

Grant and Affiliation Information for Nigral modulation of cerebello-thalamo-cortical transmission in the ventral medial thalamic nucleus.

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Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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