Nicotine exposure alters in vivo human responses to endotoxin.

Nicotine exposure alters in vivo human responses to endotoxin. Research Abstract Details 

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Nicotine exposure alters in vivo human responses to endotoxin. Abstract Text:

X Wittebole,S Hahm,S M Coyle,A Kumar,S E Calvano,S F Lowry,

The alpha 7 nicotinic receptor is reportedly a key element in the cholinergic anti-inflammatory pathway. Because a prototypical ligand for this receptor is nicotine, we studied the in vivo human response to bacterial endotoxin or lipopolysaccharide (LPS) in the context of nicotine or placebo pretreatment. Twelve adult male normal subjects were studied prospectively. Six received overnight transcutaneous nicotine administration by application of a standard patch (7 mg). Six hours later, all subjects were given an intravenous dose of endotoxin (2 ng/kg) and were evaluated for an additional 24 h for circulating levels of inflammatory biomarkers, vital signs and symptoms. The nicotine subjects had elevated blood levels of the nicotine metabolite, continine, prior to and throughout the 24-h post-endotoxin exposure phase. Subjects receiving nicotine exhibited a significantly lower temperature response as well as attenuated cardiovascular responses for 2.5-6 h after LPS exposure. In addition, increased circulating interkeukin (IL)-10 and cortisol levels were also noted in nicotine subjects. These data indicate an alteration in LPS-induced systemic inflammatory responses in normal subjects exposed to transcutaneous nicotine. In this model of abbreviated inflammation, nicotine exposure attenuates the febrile response to LPS and promotes a more prominent anti-inflammatory phenotype.

Nicotine exposure alters in vivo human responses to endotoxin. Publishing Authors By Initials

X Wittebole,S Hahm,SM Coyle,A Kumar,SE Calvano,SF Lowry,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

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Nicotine exposure alters in vivo human responses to endotoxin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental immunology

VOLUME: 147

Page Numbers: 28-34

Journal Abbreviation: Clin. Exp. Immunol.

ISSN: 0009-9104

DAY: 3

MONTH: Jan

YEAR: 2007

Nicotine exposure alters in vivo human responses to endotoxin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 57202

Nicotine exposure alters in vivo human responses to endotoxin. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Nicotine exposure alters in vivo human responses to endotoxin. Information

Substance Name: Nicotine

Registry Number: 54-11-5

Grant and Affiliation Information for Nicotine exposure alters in vivo human responses to endotoxin.

AFFILIATION: Department of Surgery, Division of Surgical Sciences, UMDNJ, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Country: England

AGENCY: United States PHS

GRANT: R37 G34695

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MEDLINETA: Clin Exp Immunol

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