Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette.

Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Research Abstract Details 

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Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Abstract Text:

Neal L Benowitz,Sharon M Hall,Susan Stewart,Margaret Wilson,Delia Dempsey,Peyton Jacob,Neal L Benowitz,Sharon M Hall,Susan Stewart,Margaret Wilson,Delia Dempsey,Peyton Jacob,

BACKGROUND: Reducing the nicotine content of cigarettes to make them non-addictive has been widely discussed as a potential strategy for tobacco regulation. A major concern with nicotine reduction is that smokers will compensate for reduced nicotine by smoking more cigarettes and/or smoking more intensively, thereby increasing their exposure to tobacco smoke toxins. This study examined whether gradual reduction in nicotine exposure increases exposure to tobacco smoke toxins. METHODS: This 10-week longitudinal study of 20 healthy smokers involved smoking their usual brand followed by different types of research cigarettes with progressively lower nicotine content, each smoked for 1 week. Subjects were followed for 4 weeks after returning to smoking their usual brand (or quitting). Smoking behaviors, chemical biomarkers of tobacco smoke exposure, and cardiovascular effect biomarkers were measured. Findings: Intake of nicotine declined progressively as the nicotine content of cigarettes was reduced, with little evidence of compensation. Cigarette consumption and markers of exposure to carbon monoxide and polycyclic aromatic hydrocarbons, as well as cardiovascular biomarkers remained stable, whereas urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol excretion decreased. Twenty-five percent of participants had spontaneously quit smoking 4 weeks after completing the research cigarette taper. Implications: Our findings with reduced nicotine content cigarettes differ from those of commercial low yields for which compensatory smoking for lower nicotine delivery is substantial. Our data suggest that the degree of nicotine dependence of smokers can be lowered without increasing their exposure to tobacco smoke toxins. Gradual reduction of nicotine content of cigarettes seems to be feasible and should be further evaluated as a national tobacco regulatory strategy. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2479-85).

Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Publishing Authors By Initials

NL Benowitz,SM Hall,S Stewart,M Wilson,D Dempsey,P Jacob,NL Benowitz,SM Hall,S Stewart,M Wilson,D Dempsey,P Jacob,

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Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 2479-85

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 16

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, Box 1220, San Francisco, CA 94143-1220. NBenowitz@MedSFGH.ucsf.edu.

Country: United States

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MEDLINETA: Cancer Epidemiol Biomarkers Pr

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